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Ara mostrant els elements 29269-29288 de 42434
Molecular determinants of human oocyte quality in assisted reproduction
Infertility, defined by the World Health Organization (WHO) as the inability to conceive after a year of unprotected sex, is a disease that affects 1 in 9 couples of reproductive age worldwide. Most of these couples will ...
Molecular determinants of the Kv1.3/KCNE4 interaction
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...
Molecular determinants of TRPV4 channel regulation
TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. Due to this ...
Molecular dynamics simulations of seven-transmembrane receptors
Seven transmembrane (7-TM) G protein coupled receptors (GPCR) constitute the largest family of integral membrane proteins in eukaryotes with more than 1000 members and encoding more than 2% of the human genome. These ...
A molecular dynamics study of nanocontact plasticity and dislocation avalanches in FCC and BCC crystals
This study aims to investigate the underlying mechanisms which govern the development of dense defect networks in nanoscale crystal plasticity, either under contact and uniaxial loading conditions, with emphasis on the ...
Molecular epidemiological studies of Porcine circovirus 3, a novel virus identified in domestic pig and wild boar
El Circovirus porcino 3 (PCV-3) es un virus descubierto recientemente en cerdos domésticos y jabalíes. El virus fue hallado por primera vez en 2016 mediante estudios metagenómicos, en animales afectados por fallo reproductivo, ...
Molecular epidemiology and mechanisms of cephalosporin resistance in escherichia coli of different origins; broilers, flies and white storks
Las bacterias resistentes a antibióticos, y en concreto a betalactamasas de espectro extendido (BLEEs), se han convertido en un problema grave. Su prevalencia ha incrementado rápidamente a nivel mundial debido a una ...
Molecular epidemiology study on genetically regulated gene expression in the colonic mucosa and its role in disease susceptibility
[spa] La expresión genética es un proceso celular clave, que además está relacionado con la susceptibilidad genética a enfermedades y rasgos complejos. La mayoría de genes se someten a splicing alternativo (AS). Las variantes ...
Molecular Evolution of Unicellular Eukaryote Metallothioneins: Tandem Repetition of Coordinating Domains
Metallothioneins (MTs) are a superfamily of ubiquitous and small cysteine rich metalloproteins present in all eukaryotes and some prokaryotes organisms, that exhibit preferences to coordinate divalent or monovalent heavy ...
Molecular genetics of autosomal dominant ataxias: identification and characterisation of two novel spinocerebellar ataxia subtypes
Les atàxies espinocerebel·loses (SCAs) consisteixen en un grup heterogeni de trastorns del moviment hereditaris caracteritzats clínicament per atàxia progressiva associada de forma variable amb altres signes neurològics ...
Molecular genetics of cork formation
La peridermis és una estructura complexa que protegeix els òrgans vegetals madurs (secundaris) i les zones que han sofert ferides de la pèrdua d'aigua i dels patògens. Aquesta funció barrera és deguda al fel·lema o súber, ...
Molecular identification and feeding ecology of arthropod generalist predators present in Mediterranean lettuce crops
The aphid Nasonovia ribisnigri (Hemiptera: Aphididae) and the thrips Frankliniella occidentalis (Thysanoptera: Thripidae) are two of the main pests in Mediterranean lettuce crops. The general goal of this Doctoral Thesis ...
Molecular insights into mammalian sperm physiology: a comparative study of glutathione S-transferases in male reproduction
Male infertility is a global health problem affecting one in four infertile couples. This also has a negative repercussion on the animal breeding industry, where infertility has a detrimental impact on their balance sheets. ...
Molecular insights into the promiscuity of serine hydrolases. Towards a computationally guided protocol for the redesign of enzymes
Two serine hydrolases, Candida antarctica Lipase B (CALB) and para-nitrobenzyl (Bs2) esterase from Bacillus subtilis, were used as a model to study enzyme promiscuity through QM/MM methods and experimental enzymes kinetics. ...
Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification
Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...
Molecular keys in structural evolution of insect ovaries
The present work aims at establishing the first bases for studying the insect oocyte polarity in a phylogenetically basal species, the cockroach Blattella germanica. Our approach was to choose some genes that have been ...
Molecular mechanism of dBigH1 action
INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...
Molecular mechanism of PE5-induced cytotoxicity and generation of new cytotoxic nuclear-directed
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
Molecular mechanisms and effect of acute and psychosocial stress on the intestinal barrier function. Implications on the irritable bowel syndrome
El estrés psicosocial es uno de los grandes problemas de salud en las sociedades modernas. En condiciones fisiológicas el estrés representa una amenaza para la homeostasis. En respuesta al estrés se genera una respuesta ...
Molecular mechanisms during the differentiation, maturation and function of marine fish spermatozoa
The molecular mechanisms regulating sperm differentiation (spermiogenesis) and maturation in fishes are largely unknown. In these oviparous species, the initiation of sperm motility is triggered by the osmolality of the ...
