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Ara mostrant els elements 37991-38010 de 42429
Structural studies of AT-rich DNA
Non-coding DNA is rich in adenines and thymines. Their unique properties, such as high polymorphism, flexibility, transitional states that lead to DNA hairpin formation and the possibility to adopt either Watson-Crick or ...
Structural studies of Heteromeric Amino acid Transporters (HATs): Validation of the first 3D structural model of a HAT (human 4F2hc/LAT2) and identification of new HAT targets for 3D‐crystallization
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide bridge. Genetic defects ...
Structural studies of recombinant TGIF1 and FBP28 WW domains using NMR and peptide ligation strategies
The present thesis is divided in three different but related projects. In the first project, the interaction between TGIF1 and SMAD proteins is investigated. TGIF1 is a transcriptional suppressor that prevents the gene ...
Structural studies on FF domains by NMR spectroscopy
El present treball s'ha realitzat en el marc del Programa de Biologia Estructural i Computacional de l'IRB Barcelona, en el grup de RMN de proteïnes, sota la direcció de la Dra María J. Macías. L'interès del grup d'investigació ...
Structural studies on human adenosine-to-inosine tRNA editing
Adenosine deaminase acting on tRNAs (ADAT) is a eukaryotic heterodimer, composed by ADAT2 and ADAT3, that catalyses the deamination of adenosine-to-inosine in the anticodon loop of tRNAs. ADAT proteins are essential for ...
Structural studies on Porphyromonas gingivalis proteins
[eng] We investigated the structure function relationship of PorX by combined biophysical experiments and enzymatic assays. As a regulator of the type 9 secretion system (T9SS) of the human pathogen Porphyromonas gingivalis ...
Structural studies on protein-protein interactions: Analysis of the regulation of the DYNLL/LC8 binding to Nek9 and characterization of the enzymes composing the arginine deiminase pathway in mycoplasma penetrans
Las interacciones proteína-proteína (PPIs, por sus siglas en inglés) son contactos físicos intencionados que se dan entre dos o más proteínas. Estas interacciones forman la red de interacciones de proteínas y forman el ...
Structural study of the therapeutic potential of protein-ligand interactions
Most of the cellular functions are driven by small-molecules that selectively bind to their protein targets. Is such their importance, that the pharmacological intervention of proteins by small molecule drugs is frequently ...
Structural system identification by dynamic observability technique
Structure system identification (SSI) can be classified as static and dynamic depending on the type of excitation. SSI by Observability Method (OM) using static tests was proposed and analyzed to address the observability ...
Structural VARs and DSGE models: applications to macroeconomics
Los argumentos de la tesis son los modelos VAR estructurales y los modelos dinámicos de equilibrio general ambos aplicados a la macroeconomía.<br/>El primer capítulo analiza, por medio de modelos VAR, los efectos de la ...
STRUCTURAL-FUNCTIONAL ANALYSIS OF LACTO-N-BIOSIDASE FROM Bifidobacterium bifidum: A POTENTIAL BIOCATALYST FOR THE PRODUCTION OF HUMAN MILK OLIGOSACCHARIDES
Els efectes beneficiosos que els oligosacàrids de la llet materna (OLM) confereixen a la salut dels lactants s'ha estudiat durant anys. Aquests oligosacàrids proporcionen una barrera protectora i un suport nutritiu essencials, ...
Structuration and Integration of Magnetic Molecules and Nanoparticles on Surfaces and Devices by Directwrite AFM Lithography
La progresiva miniaturización de los materiales a la escala nanométrica ha abierto en la última década nuevas expectativas en el campo de la Ciencia de Materiales. Dichos materiales nanométricos presentan propiedades únicas, ...
Structure and biophysical studies of mitochondrial Transcription Factor A in complex with DNA
The mitochondrial transcription factor A, TFAM, has a dual function in the organelle: it activates mitochondrial DNA transcription by binding to the HSP and LSP promoters, while in higher concentrations compacts the mtDNA. ...
Structure and dynamics of a membrane symporter: The Melibiose Permease
L’objectiu principal d’aquesta tesi doctoral ha estat estudiar el mecanisme de simport de la permeasa de melibiosa, MelB, un transportador secundari d’Escherichia coli, utilitzant mètodes experimentals (fluorescència, ...
Structure and Dynamics of Clusters and the HI Content of Spiral Galaxies, The
This thesis is focused on the implication of de dynamics of clusters on the HI content of galaxies. Target of this study has been the Virgo cluster region.<br/><br/>We have first inferred the three-dimensional galaxy ...
The structure and dynamics of complex microbe-host interaction networks
Microbes form intricate and intimate relationships with most animals and plants, many of which are crucial for host development, health and functioning. Microbe--host symbiotic associations are poorly explored in comparison ...
Structure and dynamics of ecological networks with multiple interaction types
Los organismos vivos se mantienen y reproducen a través de interacciones con individuos de su misma y de otras especies. Las interacciones bióticas son extremadamente diversas en tipo, magnitud, y escala, y dan lugar a ...
Structure and dynamics of liquid helium systems and their interaction with atomic dopants and free electrons
This thesis presents a collection of four papers published in peer-reviewed scientific journals plus a manuscript yet to be submitted, all of them in the field of low temperature physics and quantum fluids. Each of these ...
Structure and evolution of protein allosteric sites
La presente tesis estudia los sitios alostéricos desde una perspectiva estructural y evolutiva. La regulación alostérica es un aspecto fundamental de la vida a nivel molecular, ya que es el mecanismo más potente y frecuente ...
Structure and Function in Fluvials Biofilms. Implications in River DOC Dynamics and Nuisance Metabolite Production
The role of natural biofilms affecting the water quality in rivers has been the main theme in this study. Firstly, the study developed the capacity of biofilms in retention and/or production of DOC. Secondly, the study ...
