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Mechanisms of proteolytic activity regulation exerted via a unique propeptide in matrix metalloproteinases and intra/intermolecular interactions in a novel family of minimal gluzincins
Metallopeptidases are major players in the physiology and pathology of all living organisms. Their exquisite regulation is therefore essential for proper function and to prevent misdirected temporal and/or spatial proteolytic ...
Mechanisms of resistance toT-DM1 in HER2-positive breast cancer
El cáncer de mama HER2-positivo representa alrededor del 15-30% del total de pacientes con cáncer de mama. Este subtipo tiene un mal pronóstico, seguido del subtipo Triple-negativo (TNBC), que lo tiene aún peor. Actualmente, ...
Mechanisms of restricted activation of the Torso receptor: from the eggshell to the embryo
The establishment of the embryonic axis in the Drosophila embryo relies on four maternal systems. Anterior and posterior axes rely on morphogens located at the poles that will generate a gradient of activity along the ...
Mechanisms of synaptotoxicity in Alzheimer's disease : Pre- and postsynaptic differences to amyloid beta-induced injury
The mechanisms by which amyloid beta (Aβ) causes synaptic dysfunction in Alzheimer’s disease (AD) remain elusive. Aβ is derived by sequential cleavage of the amyloid precursor protein (APP) and released from neurons, but ...
Mechanisms regulating CXCR4 intracellular traffic and polarization in human hepatocellular carcinoma cells: cross-talk with the TGF-β pathway
CXCR4 is a chemokine receptor originally discovered and cloned in leukocytes that functions by controling the migration to the inflammatory foci. The CXCR4 chemokine receptor and its ligand, SDF-1α (also named CXCL12), are ...
Mechanisms responsible of sensory afferent projections into the hindbrain
Animals perceive the external world through their sensory systems, which consists in: i) sensory receptors that detect external stimuli; ii) neuronal pathways that convey the sensory information to the brain; and iii) ...
Mechanisms that regulate intracellular DNA entanglement
Topoisomerase II often produces DNA knots and catenates when its DNA strand passage activity equilibrates the topology of intracellular DNA. However, these DNA entanglements are detrimental for the normal development of ...
Mechanisms to Reduce Routing Information Inaccuracy Effects: Application to MPLS and WDM Networks
Les xarxes IP tradicionals utilitzen el model de transmissió "best-effort" per transportar tràfic entre clients de la xarxa. Aquest model de transmissió de tràfic no és el més adequat per les aplicacions en temps real com ...
Mechanistic and genetic regulation of plant responses to vegetation proximity: the roles of DRACULA2 and HFR1
La luz proporciona energía para la fotosíntesis e información sobre el medio ambiente circundante. La información lumínica avisa de situaciones desafiantes, como la proximidad de la vegetación y la sombra, que requiere de ...
Mechanistic insights into metal-catalyzed hydroamination reactions
El tema de esta tesis es el estudio DFT del mecanismo de hidroaminaciones intermoleculares catalizadas por catalizadores de rodio y oro. Los compuestos que contienen nitrógeno son muy valiosos y tienen muchos usos que van ...
Mechanistic insights into substrate-assisted catalysis in glycosidases by means of QM/MM molecular dynamics
Carbohydrates are essential molecules in biotechnology and for the proper functioning of living organisms. They are involved in energy storage, being structural components or participating in crucial biological processes ...
Mechanistic insights into the large-scale dynamics underlying different brain states
Brain activity during rest exhibits a robust intrinsic spatio-temporal structure characterized by correlated patterns of neural activity. The study of the brain in altered states of vigilance or drug-induced brain states ...
Mechanistic insights into the role of the CPEB4 neuronspecific microexon in neurodevelopmental disorders
[eng] Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of RNA-binding proteins that regulate cytoplasmic changes in poly(A) tail lengh and therefore mRNA-specific stability and translation. Since ...
Mechanistic investigations of carotenoid and ketocarotenoid biosynthesis in rice
El meu programa de recerca està enfocat a identificar els passos limitants de la biosíntesi de carotenoids en arròs (Oryza sativa) de forma que mitjançant enginyeria genètica amb múltiples gens es puguin dividir els passos ...
Mechanistic Investigations on Transition Metal-Catalyzed Asymmetric Allylic and Propargylic Substitution Reactions
Forjar estereocentres altament congestionats de manera asimètrica és de gran interès per a la indústria química fina i farmacèutica, ja que aquests motius estressats estèricament (normalment són estereocentres terciaris ...
Mechanistic Investigations to Enhance Carotenoid Content and Composition in Rice Endosperm
El meu projecte de recerca es centra en les investigacions per comprendre millor el mecanisme d'acumulació de carotenoides en call i endosperma d'arròs. Un dels principals objectius és comprendre millor el coll d'ampolla ...
Mechanistic Studies of Water Oxidation Catalyzed by Homogeneous Iron and Ruthenium Complexes and Light-driven Organic Reductions with a Dual Cobalt/Copper Catalytic System
Aquesta tesi doctoral es centra a comprendre els mecanismes implicats en l'aplicació de la fotosíntesi artificial per emmagatzemar energia solar en enllaços químics, així com desenvolupar noves metodologies respectuoses ...
Mechanistic studies on gold mediated cross-coupling reactions and total synthesis of (_+ )-epiglobulol
Tras la activación con complejos catiónicos de oro(I), los 1,6-eninos conteniendo alcoholes o éteres se pueden atrapar intra- o intermolecularmente con alquenos o éteres bencílicos. Esta reacción estereospecífica da lugar ...
Mechanistic, temporal and spatial insights of the regulatory network controlling plant responses to vegetation proximity
La llum és essencial per a les plantes, no només com a font d’energia per a la fotosíntesi, sinó també com un senyal d’informació ambiental que els permet adaptar el seu desenvolupament per prosperar en diferents escenaris. ...
Mechano-biochemical systems modelling for patient stratification in osteoarthritis
This doctoral thesis presents two different computational approaches to explore mechanistically chondrocyte dysregulation and identify biomarkers, to better understand patient stratification systems in primary knee ...
