Browsing by Title
Now showing items 29249-29268 of 42436
Molecular Basis of Ischemic Post-Conditioning: DJ-1 in Cardioprotection
Les malalties cardiovasculars són la principal causa de morbimortalitat a tot el món, essent l’infart agut de miocardi (IAM) la més prevalent. Encara que la revascularització és el tractament definitiu per a la isquèmia, ...
Molecular basis of p38a MAPK signaling
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate different ...
Molecular basis of shade tolerance: identification of novel components
Per fer front a la limitació de llum que podria provocar l’ombra de la vegetació veïna, les plantes han desenvolupat dues estratègies diferents i divergents: l’evitació, com Arabidopsis thaliana, i la tolerància, com la ...
Molecular basis to human P-glycoprotein reversion
ABC (ATP-binding cassette) transporters are involved in translocate a wide spectrum of molecules across the lipid bilayer and some of them are associated with various diseases. They also have an important role in multidrug ...
Molecular characterisation of the underlying mechanisms of pathogen-associated molecular pattern (PAMP) recognition in fish
La respuesta inmune innata es basada en la activación de receptores genotípicamente codificados, llamados receptores de reconocimiento de patógenos (PRR). Los PRR pueden ser proteínas solubles tal como las proteínas ...
Molecular Characterization and Novel Therapeutic Approaches in Hepatocellular Carcinoma
[eng] 1. HYPOTHESES. Primary liver cancer is the sixth most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide2,3. Around 90% of cases correspond to hepatocellular carcinoma (HCC)2,3, ...
Molecular characterization of carnitine palmitoyltransferase 1C
Carnitine palmitoyltransferase 1 (CPT1) catalyzes the conversion of long chain fatty acyl-CoAs into acylcarnitines, the first step in the transport of long chain fatty acids from the cytoplasm to the mitochondrial matrix, ...
Molecular characterization of High Risk Neuroblastoma. Potential biomarkers for high-risk neuroblastoma classification
[eng] BACKGROUND: High-risk neuroblastoma (NB) represents a heterogeneous group of tumors, whereby patients can display response to treatment and long-term outcome or develop early progressive, chemoresistant disease with ...
Molecular characterization of microbial diversity in wastewater treatment and reuse
La generació d’aigua residual és una conseqüència inevitable de les activitats humanes. Aquestes activitats modifiquen les característiques de les aigües de consum, contaminant-les i invalidant la seva posterior aplicació ...
Molecular characterization of neurofibromatosis type 1–associated malignant peripheral nerve sheath tumours and functional identification of genes involved in their pathogenesis
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...
Molecular characterization of pluripotency in embryos and embryonic stem cells
Pluripotent cells are unique due to their developmental potential and the possibility to study them is the key step to understand human development. These cells are characterized by their ability to originate all the ...
Molecular Characterization of the circadian clock in Solanum lycopersicum
El rellotge circadià és un mecanisme molecular de mesura del temps que genera ritmes d'aproximadament 24 hores en el metabolisme i la fisiologia, en sincronització amb el cicle de dia i nit. Durant l'última dècada, la ...
Molecular characterization of the circadian function and the transcriptional regulatory network at the core of the pistil circadian clock
El rellotge circadià és un mecanisme cel·lular endogen que genera ritmes biològics amb un període de 24 hores. A les plantes, el sistema circadià regula molts processos essencials, inclosos, entre d'altres, el temps de ...
Molecular characterization of the microenvironment in CLL-like monoclonal B cell lymphocytosis and early-stage chronic lymphocytic leukemia
The analysis of the microenvironment in CLL-like monoclonal B cell lymphocytosis (MBL) and early-stage chronic lymphocytic leukemia (CLL) is relevant for understanding the natural history of CLL. To this end, a total of ...
Molecular characterization of the Ppz1 phosphatase and its regulatory subunit Hal3
La proteína Ser / Thr fosfatasa Ppz1 de S. cerevisiae es un componente importante en el mantenimiento de la homeostasis de cationes monovalentes (K+ y Na+) y, como tal, incide en múltiples procesos celulares, tales como ...
Molecular charaterization of Primary Ciliary Dyskinesia|
Introduction: Motile cilia are highly complex hair-like organelles protruding from the apical surface of epithelia cells of various human organ systems. They contain a 9+2 tubulin-based axoneme core structure and an ...
Molecular classification and biomarkers in hepatobiliary cancer
[spa] El cáncer hepatobiliar (incluye principalmente el carcinoma hepatocelular [HCC] y el cáncer del tracto biliar [BTC]) representa la tercera causa de muerte relacionada con cáncer en todo el mundo [1]. Menos de la mitad ...
Molecular containers based on aryl-extended calix[4]Pyrroles
Aquesta Tesi s'ocupa del disseny i síntesi de receptors còncaus que posseeixen cavitats hidrofíliques: receptors covalents, caixes metàl·liques i càpsules no covalents. Per a la seva construcció, triem la bastida de ...
Molecular containers based on calix[4]pyrrole scaffolds
Aquesta tesi compren la síntesi i l'estudi de diferents contenidors moleculars basats en una estructura macrocíclica de calix[4]pirrol. Els contenidors moleculars poseeixen cavitats polars funcionalitzades ideals per al ...
