Browsing by Title

An epigenetic approach to fatty acid metabolism in haematological malignancies

Maher, Michael (Date of defense: 2021-05-07)

The role of fatty acids to overcome stress and contribute to disease progression is becoming increasingly evident in haematological diseases. Further, epigenetic factors play an important role in the aetiology of myelodysplastic ...

Epigenetic deregulation of WT1 and AWT1 in hematological maligancies

Guillaumet Adkins, Amy Lauren (Date of defense: 2012-12-13)

En l’última dècada, s’ha posat en evidència que el càncer és tant una malaltia genètica com epigenètica. La desregulació epigenètica pot afectar molts processos cel·lulars, com són el silenciament de gens supressors de ...

Epigenetic Dysregulation of Monocytes as a Sensor of Activity and Progression in Arthritis

Calle Fabregat, Carlos de la (Date of defense: 2022-03-15)

OBJECTIVE: Identifying predictive biomarkers at early stages of undifferentiated arthritis (UA) is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely associated with ...

Epigenetic information contained in male germ cell chromatin-associated proteins and its potential impact on the reproductive function

Iglesia Rodríguez, Alberto de la (Date of defense: 2022-10-28)

[eng] Contrasting the traditional idea of the male gamete being a simple carrier of the paternal DNA, evidence in the last decades revealed that the sperm cell provides the embryo with different layers of epigenetic ...

Epigenetic inheritance and DNA replication in Caenorhabditis elegans

Reis, Kadri (Date of defense: 2016-03-23)

Una gran proporción del genoma de la mayoría de eucariotas superiores está formado por secuencias repetitivas de DNA que contienen señales de represión de la transcripción. Para entender mejor cómo funciona la herencia ...

Epigenetic mechanisms in colorectal cancer

Custodio Rojo, Joaquín (Date of defense: 2014-10-15)

Mitjançant tècniques d’anàlisi de tot el genoma hem sigut capaços d'identificar regions diferencialment metilades entre teixit de colon normal i tumoral provinents del mateix pacient. Un dels gens més importants és AKR1B1, ...

Epigenetic Mechanisms in Monocyte-Associated Differentation and Inflammation Processes

Vento Tormo, Roser (Date of defense: 2016-01-22)

En aquesta tesi s’han estudiat els mecanismes epigenètics implicats en diferents processos d’inflamació i diferenciació a partir de monòcits (MO). És possible recapitular la diferenciació terminal de MO a cèl·lules ...

Epigenetic Mechanisms in two primary immunodeficiencies: Hyper-IgM Syndrome and Common Variable Immunodeficiency

Rodríguez Cortez, Virginia Carolina (Date of defense: 2015-02-06)

The proper function of the immune system requires complex regulatory mechanisms and a highly strict balance in the amount and function of immune and non-immune elements. Part of the primary immunodeficiencies result from ...

Epigenetic regulation mediated by antisense non-coding RNAs and its impact on oncogenic pathways: the HMGA2/RPSAP52 locus

Oliveira Mateos, Cristina (Date of defense: 2020-06-16)

The vast majority of the human genome is transcribed giving rise to non-coding RNAs. Antisense transcripts are one of the most abundant types of long non-coding RNAs and many of them have regulatory roles in the transcription ...

Epigenetic regulation of 5-methylcytosine RNA modification in human cancer

Ortiz Barahona, Vanessa (Date of defense: 2022-04-01)

The general aim of this thesis is to identify and characterize if there are DNA methylation patterns giving rise to cancer-related m5C RNA modification defects, potentially promoting malignant transformation and tumor ...

Epigenetic regulation of clonally variant gene expression in Plasmodium falciparum

Crowley, Valerie Margarita (Date of defense: 2011-11-02)

Clonally variant gene expression (CVGE) is a common survival strategy used by many pathogens, including the malaria parasite Plasmodium falciparum. Among the genes that show CVGE are several members of the clag and eba ...

Epigenetic regulation of lysine acetylation: targeting writers, readers and erasers in cancer

Pérez Salvia, Montserrat (Date of defense: 2019-03-01)

Cancer is considered nowadays a genetic and epigenetic disease. Aberrancies in epigenetic marks in DNA and histone tails together with alterations in epigenetic regulators responsible of catalyzing these marks have been ...

Epigenetic regulation of the transcriptome

Borsari, Beatrice (Date of defense: 2021-03-26)

We have monitored the transcriptome and the epigenome of human pre-B cells transdifferentiating into macrophages. Analysis of these data provides a general framework to understand the relationship between gene expression ...

Epigenetic Regulation of tRNA Biology in Cancer

Rosselló Tortella, Margalida (Date of defense: 2021-12-09)

Transfer RNAs (tRNAs) are essential molecules that allow the translation of the genetic code into amino acids. Extensive research during the last 50 years have revealed that, despite their apparently simple structure and ...

Epigenetic regulators in neuroblastoma: BRG1, a future therapeutic target

Jubierre Zapater, Luz (Date of defense: 2017-10-09)

El Neuroblastoma (NB) es un cáncer derivado del sistema nervioso simpático, y es el tumor sólido más común en los niños de cero a dos años. Los NB son muy heterogéneos, tienen un curso clínico que puede variar desde la ...

Epigenetics in alternative splicing : links between chromatin structure, transcription and non-coding RNA mediated regulation

Agirre Ortiz de Guzmán, Eneritz (Date of defense: 2013-06-21)

Generalment s'ha pensat que la regulació de l'splicing alternatiu està controlada principalment per la interacció entre els factors reguladors de l'splicing i la taxa d'elongació de la ARN polimerasa II (RNAPII). Hi ha ...