Genetic factors associated with coronary heart disease and analysis of their predictive capacity 

Lluís Ganella, Carla (Date of defense: 2012-06-26)

The main expansion of the discovery of genetic variants associated with complex diseases has occurred during the last decade. This expansion has been accompanied, and in some sense motivated, by the desire to use this ...

Genetic gains and changes in the pattern of adaptation of bread wheat varieties grown in Spain during the 20th century 

Sánchez García, Miguel (Date of defense: 2012-11-05)

Genetic Insights into the Heterogeneity and Comorbidity of Substance Use Disorders 

Vilar Ribó, Laura (Date of defense: 2023-11-20)

[eng] Substance use disorders (SUDs) are psychiatric disorders characterized by a recurring desire to continue taking a substance regardless of its destructive consequences. The etiology of SUDs is complex and multifactorial, ...

Genetic introgression in chimpanzees and bonobos 

Manuel Montero, Marc de (Date of defense: 2018-12-11)

Els nostres parents més propers, els ximpanzés i els bonobos, tenen una història demogràfica complexa. En aquest estudi, hem analitzat els genomes sencers de 75 ximpanzés i bonobos nascuts en 10 països diferents d'Àfrica. ...

Genetic manipulation of the pancreas: cell and gene therapy approaches for type 1 diabetes 

Ayuso López, Eduard (Date of defense: 2006-06-30)

La diabetes de tipo 1 resulta de la destrucción autoinmune de las células ß pancreáticas, que conduce a una falta en la producción de insulina y la consiguiente hiperglucemia. La terapia sustitutiva con inyecciones subcutáneas ...

Genetic polymorphism in goat. Study of the kappa casein, the betalactlobulin and the coenzyme a desaturasegenes 

Yahyaoui, Mohamed Habib (Date of defense: 2003-07-30)

Genetic Polymorphisms of RANK, RANKL and their relation to osteoporosis (Polimorfismos genéticos de RANK y RANKL y su relación con la osteoporosis) 

Yoskovitz, Guy (Date of defense: 2012-12-05)

Osteoporosis is a systemic skeletal disorder and the most common metabolic bone disease. It is recognized as one of the most prevalent problems facing postmenopausal women in western society. The World Health Organization ...

Genetic profile of Western Mediterranean populations: contributtion of Arab and Jewish groups 

Bentayebi, Kaoutar (Date of defense: 2012-06-09)

Este trabajo describe la diversidad genética de las poblaciones actuales del Oeste del Mediterráneo según dos polimorfismos: nueve polimorfismos Alus y doce microsatelites (STR) presente en el cromosoma X. En este trabajo, ...

Genetic Risk Factors for the Lack of Response to Clinical Treatment in Mental Disorders: an Approach from Pharmacogenetics 

Mitjans Niubó, Marina (Date of defense: 2014-12-17)

Severe mental disorders, such as Major Depressive Disorder (MDD), Bipolar Disorder (BD) and Schizophrenia (SCZ), represent a huge burden to society, reflecting the limited efficacy of current drug treatments. Although the ...

Genetic risk factors in Schizophrenia and Neurodevelopmental disorders: Association and epistatic analyses of Neuritin-1 gene and white matter related genes = Factores genéticos en esquizofrenia y enfermedades del neurodesarrollo: análisis de asociación y epistáticos en el gen Neuritina-1 y en genes relacionados con la materia blanca 

Prats Balado, Claudia (Date of defense: 2017-09-29)

Nowadays, it is estimated that about 450 million people suffer from a mental or behavioural disorder in the world. According to World health organization (WHO), 33% of the years lived with disability (YLD) are due to ...

Genetic structure of North African human populations : A complex history of admixture 

Rubio Araúna, Lara (Date of defense: 2017-12-14)

North African populations show a complex genetic structure characterized by the admixture of at least four different components: Middle Eastern, sub-Saharan, European and autochthonous North African. However, there are few ...

Genetic studies of emotional behaviour in rats 

Mont i Cardona, Carme (Date of defense: 2015-01-23)

Aquest treball doctoral explora dues aproximacions a l’estudi de la conducta a través de la genètica. La primera és una aproximació de caire intervencionista l'objectiu de la qual és estudiar la funció conductual de la ...

Genetic variability and telomere length in bariatric surgery outcomes in obese patients 

Peña Lozano, Elionora (Date of defense: 2020-11-13)

Based on the background showing i) that obesity have a polygenic nature with the implication of different genes of minor effect and lifestyle factors; ii) the high variability between individuals in weight loss outcome ...

Genetic variability of minnows and loaches in rivers and high mountain lakes from the Pyrenees and Italian Alps 

Suh, Jongmo (Date of defense: 2024-02-20)

[eng] The invasion of alien species is a major global threat to ecosystems, with significant impacts, especially on freshwater ecosystems. The species diversity in freshwater ecosystems has significantly declined worldwide, ...

Genetic variation and complex rearrangements in Autism Spectrum Disorders: implications for genetic counseling 

Codina i Solà, Marta (Date of defense: 2016-07-14)

The etiology of Autism Spectrum Disorders (ASD) remains unknown for most of the cases, in spite of its strong genetic component. A greater knowledge of its genetic basis would result in many benefits, including specific ...

Genetic variation in human miRNAs : functional consequences and involvement in Cancer 

Torruella Loran, Ignasi (Date of defense: 2016-10-28)

Els microRNAs són importants reguladors de gens i destacats contribuïdors a la diversitat fenotípica clarament involucrats en malaltia humana. Hem analitzat la variabilitat genètica en microRNAs i como aquesta variabilitat ...

Genetic variation in humans and chimpanzees in the prion protein gene 

Soldevila Trepat, Marta (Date of defense: 2005-06-20)

En el gen de la proteïna priònica, o PRNP, hem observat que el particular patró de variació que hem trobat basant-nos en dades de seqüenciació en humans es deu a selecció positiva, i que el mètode utilitzat per detectar ...

Genetic variation in serotonergic system genes: vulnerability for major depression and pharmacogenetics of response to SSRI antidepressants 

Arias Sampériz, Bárbara (Date of defense: 2003-01-01)

1. Objetivo General: Estudiar la variación existente en genes candidatos implicados en la neurotransmisión serotoninérgica como factor de riesgo en la depresión mayor y como factor relacionado con aspectos del fenotipo ...

Genetic variation of the X chromosome and the genomic regions of Coagulation Factors VII and XII in human populations: Epidemiological and evolutionary considerations 

Athanasiadis, Georgios (Date of defense: 2010-07-14)

In this work we have analyzed the variation of (i) several X chromosome polymorphic Alu insertions and (ii) several SNPs and microsatellites within and around the genomic regions of the genes coding for coagulation factors ...

Genetic, genomic and epigenetic alterations in congenital malformations : implications in genetic counseling 

Serra Juhé, Clara (Date of defense: 2012-10-20)

Mechanisms underlying congenital malformations are largely unknown despite its high incidence, affecting 2-3% of liveborn infants. A broader knowledge about the causes of birth defects would provide valuable information ...