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Immunopathogenesis of postnatal persistent infection generated by classical swine fever virus and its implication in the superinfection exclusion phenomenon
La peste porcina clásica (PPC) es una enfermedad viral altamente contagiosa de cerdos domésticos y salvajes, incluida en la lista de enfermedades de declaración obligatoria a la Organización Mundial de Sanidad Animal. El ...
Immunoreceptor MerTK: A journey from the membrane into the nucleus of human dendritic cells
Discrimination between foreign and potentially harmful antigens, and the body’s own tissue is one of the most crucial first steps that lays at the basis of a proper immune response. Immunoreceptors are cell membrane embedded ...
Immunoregulation of porcine dendritic cells by influenza viruses and Haemophilus parasuis: lessons from in vitro studies
El virus de la gripe porcina (SwIV) es una zoonosis. El hecho de que los cerdos pueden actuar como "cocteleras virales" del virus de la gripe potencialmente infecciosos para el ser humano pone de manifiesto su relevancia ...
Immunosenescence in multiple sclerosis: innate immunity as a possible therapeutic target
L'esclerosi múltiple (EM) és una malaltia crònica, inflamatòria, desmielinitzant i neurodegenerativa del sistema nerviós central (SNC). Encara que la seua etiologia continua sent desconeguda, l'edat és un factor important ...
Immunoteràpia de l'artritis adjuvant amb anticossos monoclonals antilimfocítics
L'artritis reumatoide (AR) és una malaltia crònica localitzada principalment en les articulacions, on es produeix inflamació de la membrana sinovial, degeneració del cartílag i l'os, que finalment originen la seva deformació ...
Immunotherapy against HER2-positive breast cancers
El 20% de los tumores mamarios sobre expresan el receptor de tirosina quinasa HER2, debido a su amplificación génica, tanto dentro de los cromosomas (HSR) como fuera ellos (DM). Se sabe muy poco acerca de la respuesta ...
Immunotherapy for alzheimer’s disease: from antibody engineering to combined therapy with apolipoproteins.
ScFv-h3D6 és un fragment variable de cadena lleugera, derivat de l’anticòs bapineuzumab, capaç d’evitar la citotoxicitat induïda pel pèptid Aβ, retirant els oligòmers de la via amiloide cap a una via d’agregació worm-like ...
Immunotherapy of chronic virus infections : Exhausted CD8+ T cell subsets are differentially regulated by XCR1 + DC
The contribution of cross-presenting XCR1+ dendritic cells (DC) in maintaining T cell function during exhaustion and immuno-therapeutic interventions of chronic infections remains poorly characterized. Using the mouse model ...
Immunotherapy with memory “stem” Tcells modified with chimeric antigenspecific receptors (CARs) for patients with lymphoid neoplasms
La teràpia cel·lular adoptiva amb cèl·lules T modificades amb un receptor quimèric antigen-específic (CAR) dirigit contra CD19 ha demostrat resultats excel·lents en les neoplàsies de cèl·lules B. No obstant això, la seva ...
Impact assessment of the façades' actual state on the energy performance gap of residential buildings
Bridging the gap between the predicted and actual energy performance of buildings is necessary to increase the energy performance of existing buildings and achieve the European Union’s energy efficiency targets in the “2030 ...
Impact hazard associated with large meteoroids from disrupted asteroids and comets
El impacto de grandes fragmentos desprendidos de cometas y asteroides contra la Tierra puede llegar a ser muy peligroso. Recientemente, sucesos como Chelyabinsk (2013), Carancas (2007) o Tunguska (1908) han demostrado la ...
Impact of a SIGLEC1 null variant on the pathogenesis of HIV-1 and Mtb infection
Les cèl·lules presentadores d’antigen de llinatge mieloide tenen la capacitat de respondre a una infecció d’una manera ràpida i eficient coordinant respostes immunitàries innates i adaptatives. Malgrat això, en el cas de ...
Impact of adipose tissue on endothelial cells: effect of metabolic disorders
This thesis aims to progress in deciphering the effect of the cytokines secreted by the visceral adipose tissue of obese individuals with type 2 diabetes on the endothelium, and therefore contribute to the understanding ...
Impact of adult students' time perspective on time-on-task and learning performance using game based learning
The use of game-based learning (GBL) methodologies is increasing in online higher education in general, and in business education in particular, despite the small amount of research that exists on the effectiveness of these ...
Impact of Alzheimer's disease risk factors on white matter hyperintensities and cognition in cognitively unimpaired individuals
White matter hyperintensities (WMH) have been associated with increased risk and progression of Alzheimer’s disease (AD). However, the range to which this association can be extended to AD risk factors and WMH burden in ...
Impact of cancer cell plasticity on tumor immune microenvironment and immunotherapy response
[spa] La mayoría de los carcinomas escamosos de piel (cSCCs) se tratan con éxito mediante escisión quirúrgica. Sin embargo, el 5-8% de los casos desarrollan recurrencias, las cuales están asociadas a un crecimiento ...
IMPACT OF CHANNEL STATE INFORMATION ON THE ANALYSIS AND DESIGN OF MULTIANTENNA COMMUNICATION SYSTEMS
Al llarg d'aquesta última dècada, s'ha produit un creixement constant en la demanda d'elevades taxes de transmissió de dades que han de suportar les aplicacions sobre comunicacions sense fils. Entre les diferents solucions ...
Impact of Childhood Trauma on Levels of Depressive Symptoms, Pain, Functionality, and Cognitive Conflicts in Fibromyalgia
[eng] In recent years, much scientific evidence has shown the role of child maltreatment in human development, which impacts all aspects of growth, physical, behavioral, emotional, and cognitive. Depending on the extent ...
Impact of chlorophenols and heavy metals on soil microbiota: their effects on activity and community composition, and resistant strains with potential for bioremediation
Pollution by toxic compounds is one of the most relevant environmental damages to ecosystems produced by human activity and, therefore, it must be considered in environmental protection and restoration of contaminated ...
The impact of chromosome positioning in nuclear functions
Chromatin is not randomly organized inside the eukaryotic nucleus in interphase. In budding yeast gene expression of some specific loci is affected by their positioning in the nucleus. Replication firing of early origins ...
