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Novel Disulfide Formation Strategies in Peptide Synthesis
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...
Novel electrochemical approaches to micro- and nanoscale metallic materials for advanced magnetic and energy applications: Co-In, Fe-Rh and Fe-P systems
La presente tesis doctoral abarca la síntesis electroquímica y caracterización de las propiedades tanto físicas como fisicoquímicas de tres sistemas binarios diferentes, el cobalto-indio (Co-In), hierro-rodio (Fe-Rh) y ...
A novel electrochemical platform based on screen printed carbon electrodes (SPCEs) for molecular diagnostics
L’objectiu d’aquest treball és desenvolupar dispositius de diagnòstic molecular electroquímics de baix cost basats en microsistemes d’elèctrodes serigrafiats. Aquesta tesi es centra en mètodes per incrementar la reproduibilitat ...
Novel electron acceptors and new solution processed hole blocking layer for organic solar cells
La utilització de materials orgànics per a la fabricació de cèl·lules solars és una de les alternatives considerades actualment per a reduir els costos de fabricació de sistemes fotovoltaics. Els materials orgànics tenen ...
Novel electronic stretchable materials for future medical devices
L’electrònica convencional basada en el silici te grans dificultats a l’hora de ser implementada en dispositius electrònics que estiguin en contacte amb les corbes i las plasticitat dels teixits del cos humà. Futures ...
Novel Enantioselective Aminocatalytic Processes by means of Vinylogous Reactivity and Photoredox Catalysis
En aquesta tesi es mostra com la aminocatàlisis pot ser utilitzada per resoldre diferents problemes en síntesis orgànica. La combinació de la aminocatàlisis amb el concepte de la vinilogia per tal de funcionalitzar ...
Novel experimental strategies to treat multiple sclerosis
A pesar de que la esclerosis múltiple fue descrita por el Dr. Jean-Martin Charcot en el siglo XIX, todavía sigue siendo una enfermedad neurológica desafiante. La etiología de la enfermedad es desconocida, pero se sabe que ...
Novel femtosecond optical parametric oscillators in the infrared
High-repetition-rate femtosecond laser sources are essential laboratory tools for spectroscopy, microscopy, amongst other applications. With the relative length of one femtosecond to one second being similar to the length ...
Novel functionalized and patterned surfaces for cardiovascular applications
Nowadays, cardiovascular diseases are mainly treated by implantation of a metallic or polymeric mesh, called stent, which maintains the artery widely open. This technique shows very good clinical results, however, it exists ...
Novel functions and interactors for Brassinosteroid receptors In Arabidopsis thaliana = Noves funcions i interactors pels receptors de Brassinosteroids d’Arabidopsis thaliana
The general objective of this PhD thesis is to investigate the mechanistic bases for plant hormones Brassinosteroids (BRs) action in plant vascular development. To this end, we have used a multidisciplinary approach by ...
Novel genetic mechanisms in autoinflammatory diseases : Contribution of somatic and germline variation
Autoinflammatory diseases are caused by an antigen independent hyperactivation of inflammatory pathways. The first genetic defect linked to an autoinflammatory disease was described almost 25 years ago and, since then, the ...
Novel Halogen(I) Reagents in the C-sp3- and Csp3-Bond Functionalization
En el treball presentat en aquesta tesi es mostren els desenvolupaments importants realitzats sobre l’ús de reactius d'halogen(I), específicament en la funcionalització d’enllaços C(sp2)-H i C(sp3)-H mitjançant reactius ...
Novel high-resolution BAW ultrasonic sensors based on CMOS-compatible AlN transducers operated in a pulse-echo scheme
Les tecnologies i els dispositius d’ones acústiques han estat en ús comercial per a telecomunicacions, detecció de pressió per a automoció, proves no destructives i atenció mèdica durant més de 60 anys; la seva aplicació ...
Novel insights in nicotine addiction : focus on cognitive function
Cigarette smoking continues to be leading cause of preventable cause of death worldwide. Cognitive modulation by nicotine seems to be a key factor in nicotine addiction. Several studies indicate that initial nicotine intake ...
Novel insights in occupational asthma due to persulfate salts
El asma relacionada con el trabajo se define como el asma causada por la exposición a agentes que se encuentran en el lugar de trabajo, y es responsable de hasta un 25% de los casos de asma de inicio en la edad adulta. En ...
Novel insights into paternal factors influencing the maternal environment and embryo development
For many years, reproductive outcomes were considered as being solely determined by the genome of oocytes and sperm. Yet, in the last decades, many other female and male factors have also been found to be relevant. Focusing ...
Novel light management techniques for thin film solar cells: Nanotextured substrates and transparent conducting upconverters
The objective of this work was to study two different light management approaches to enhance the efficiency of thin film Si solar cells and these were the manipulation of the light path (light trapping) and changing the ...
Novel Lipases: Expression and Improvement for Applied Biocatalysis = Nuevas lipasas: expresión y mejoras para biocatálisis aplicada
This thesis is focused in the identification and improvement of lipases for biotechnological application. The importance of lipases is increasing in several industries. However, the commercial use of lipases is still a ...
Novel lubrication system to improve the excessive wear in wind turbine yaw and pitch gears
Manufacturers of wind turbines have observed a new phenomenon that appears in high power wind turbines: excessive wear in the teeth located at 0º in the pitch bearing. In order to design more efficient wind turbines, ...
Novel markers and targets of collective tumor cell invasion before and after anti-angiogenic therapies
Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and collective invasion. ...
