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Now showing items 19665-19684 of 41814
Genome basis for functional differentiation in uncultured lineages of marine bacterivores
In the vast network of the ocean, microbes are abundant and unevenly distributed. As an important microbial component, the protists play a key role in global biogeochemical cycles and contribute to the recycling of nutrients ...
A genome editing based approach to study tumor cell heterogeneity
Colorectal tumors are not homogeneous entities but rather composed of a mixture of cells with different phenotypes, reminiscent of healthy intestinal epithelium cell types. Intestinal epithelium is one of the organs with ...
Genome-wide association analysis of meat quality and gene expression phenotypes in Duroc pigs
El principal objetivo de la presente tesis fue identificar regiones genómicas asociadas con la variación fenotípica de caracteres relacionados con la calidad de la carne. Para ello se realizaron estudios de asociación ...
Genome-wide transposon analyses: annotation, movement and impact on plant function and evolution
The diversity of life forms around us is astounding: a walk in the woods, or even down the street, shows us organisms of different morphologies: two legs, four legs, wings; different capacity of interaction with our ...
Genomic analyses of the cup-shaped cotyledoni 1 network
El desarrollo de la flor ha sido un importante campo de investigación por muchos años y el análisis extensivo de interacciones genéticas resultó en un marco de referencia que permitió entender cómo se produce la especificación ...
Genomic analysis of an introduced ascidian and implications for invasiveness
Invasive species constitute a major threat to global biodiversity and cause important economic losses and ecological impacts. In the marine realm, ascidians include several aggressive invasive species, some of which have ...
Genomic analysis of dairy and pigmentation traits in Murciano-Granadina goats
Amb l'objectiu d'obtenir nous coneixements sobre la base molecular de la lactació en cabres de la raça Murciano-Granadina (MUG), hem dut a terme una anàlisi RNA-Seq de mostres de la glàndula mamària (N=7) obtingudes en ...
Genomic analysis of epithelial fusion and wound healing morphogenetic processes in Drosophila / Análisis genómico de los procesos morfogenéticos de fusión de epitelios y cicatrización en Drosophila
This thesis is based on a genomic study of the epithelial fusion and wound healing processes using Drosophila melanogaster as a model system. The aimed of the work is to study the genomic differences between cells actively ...
Genomic analysis of fatty acid composition and gut microbiota in pigs
La carne de cerdo es una de las carnes más consumidas en el mundo, cuyo valor se ve afectado por su calidad y las preferencias del consumidor. La composición de los ácidos grasos (AGs) en músculo y tejido adiposo modifica ...
Genomic analysis of wild and captive chimpanzee populations from non-invasive samples using target capture methods
Wild chimpanzee populations are considered to be under threat of extinction due to the damaging consequences of human impact into their natural habitat and illegal trade. Conservation genomics is an emerging field that has ...
Genomic and functional approaches to genetic adaptation
The genetic basis of phenotypes that have contributed to the adaptation of species and organisms to new environments is a central question in evolutionary genetics. The recent accumulation of genetic variability data has ...
Genomic and functional genomic analysis of fatty acid composition in swine
El cerdo es una de las principales fuentes de carne consumida por el hombre y las preferencias de los consumidores hacia productos de alta calidad han aumentado durante los últimos años. Por lo tanto, conocer los mecanismos ...
Genomic approaches for the identi cation of risk loci for Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is one of the most prevalent autoimmune diseases in the world and is characterized by the chronic in ammation of the synovial joints. The origin of the disease is unknown but it is actually ...
Genomic changes driving the acquisition of multidrug resistance in Candida glabrata
This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to find the mutational ...
Genomic characterisation of brain malignancies through liquid biopsies: The cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
Los recientes avances en la secuenciación masiva en paralelo y en las técnicas genómicas digitales apoyan la validez clínica del ADN libre tumoral circulante (ctDNA) como una "biopsia líquida” en el cáncer humano. La ...
Genomic Characterization of Human Long Noncoding RNAs
The human genome contains an astonishingly large fraction of noncoding DNA, which is pervasively transcribed into thousands of long noncoding RNAs (lncRNAs) -- long transcripts with no discernible protein-coding potential. ...
Genomic determinants of chronic lymphocytic leukemia progression: from individual drivers to a heterogeneous genetic makeup
Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in Western countries. Although the disease might follow an indolent course, it rapidly progresses in a fraction of cases, become resistant to ...
Genomic distribution and functional specificity of human histone H1 subtypes
Seven linker histone H1 variants exist in human somatic cells with distinct prevalence among cell types and during differentiation. Despite being key chromatin structural components, it remains elusive how they participate ...
Genomic divergence along the continuum of speciation in a recent evolutionary radiation of montane grasshoppers
Unraveling the proximate processes that have shaped genetic variation of populations and led to lineage diversification and speciation is fundamental to understand the origin of present-day biodiversity patterns at both ...
