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Now showing items 35597-35616 of 41912
Role of CLA+T lymphocytes in the mechanisms triggering psoriasis
Psoriasis is a common immune-mediated inflammatory skin condition affecting around 2% of the population worldwide. Different disease subtypes have been described regarding their specific clinical phenotype: chronic plaques, ...
The Role of Cognitive Ability in the Acquisition of Second Language Perceptual Phonological Competence
Many second language (L2) learners find L2 pronunciation difficult and experience perception and production problems leading to accented speech. There exists a great inter-learner variation in L2 phonological acquisition ...
The role of community-based tourism in sustainable rural development : case studies from Ecuador
The global environmental change affects rural communities in an unprecedented way and brings transformations in the livelihoods in rural households. Rural households have a growing vulnerability to climate and non-climate ...
Role of connexin 43 in ischemia-reperfusion injury: Effect of genetic connexin 43 manipulation on myocardial cell death and arrhythmias
El daño miocárdico por isquemia-reperfusión es una de las principales causas de morbilidad y mortalidad. La reperfusión es el tratamiento de elección en pacientes con infarto de miocardio. Sin embargo, ésta ocasiona un ...
The Role of Copper in Homogeneous Catalysis: Single Electron Transfer and Beyond
Una major comprensió de les reacciones orgàniques catalitzades per Cu és altament desitjable, especialment en els casos on s’involucren passos de transferència d’un electró. En aquesta tesis, realitzem càlculs DFT dels ...
Role of CPT1C in breast cancer development and chemoresistance
Carnitine palmitoyl transferase 1 (CPT1) are enzymes that catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, to transport long-chain fatty acids across intracellular membranes. CPT1C isoform is highly ...
Role of CREB/CRTC1-regulated gene transcription during hippocampal-dependent memory in Alzheimer’s disease mouse models
Cambios en la transcripción de genes en el cerebro están asociados a alteraciones sinápticas y deterioro cognitivo tanto durante el envejecimiento normal como en trastornos cognitivos relacionados a la edad. Sin embargo, ...
The Role of cross-modal semantic interactions in real-world visuo-spatial attention
In our everyday life we must effectively orient attention to relevant objects and events in multisensory environments. The impact of cross-modal links for attention orienting to spatial and temporal cues has been widely ...
The Role of cyclin O in the DNA damage response
Cyclin O, a novel identified CDK1 and CDK2-binding cyclin, has been demonstrated to be required for γ-radiation induced apoptosis in a lymphoid cell line. Ɣ-radiation induces the formation of DSBs in the DNA what activate ...
Role of cytoplasmic cyclin D1 in radial migration of cortical neurons during brain development
Ciclina D1 pot interaccionar amb CDK4/6 per promoure el pas de la fase G1 a S en el cicle cel·lular. Recentment, s'ha descobert que cèl·lules cancerígenes sobreexpressen Ciclina D1 per al creixement tumoral, però també ...
Role of D-fagomine and omega-3 plyunsaturated fatty acids on gut microbia and related metabolic changes in healthy rats and in a model of fat-induced prediabetes
Modern lifestyles in an increasing number of human societies include consuming an excess of saturated fats and refined sugars as well as enjoying microbiologically aseptic environments. Maintaining the appropriate ...
Role of DOR/TP53INP2 in the control of muscle protein degradation = Papel de DOR/TP53INP2 en el control de la degradación de proteínas en el músculo esquelético
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear bodies. However, in ...
Role of DPPA3 in hypoxia and tumour dormancy in cancer
Colorectal cancer (CRC) is a leading cause of death worldwide and tumour recurrence is a frequent complication that arises from minimal residual disease and shows up after a period of clinical dormancy. Slow-cycling cancer ...
Role of DYRK1A in hippocampal neuroplasticity : implications for Down syndrome
Synaptic connections in the brain respond throughout their lives to the activity of incoming neurons, adjusting their biological properties to increment activity-dependent changes. Hippocampal neuronal plasticity disruptions ...
Role of DYRK1A in the development of the cerebral cortex : Implication in Down Syndrome
In this work we have assessed the possible contribution of the human chromosome-21 gene DYRK1A in the developmental cortical alterations associated with Down Syndrome using the mBACTgDyrk1a mouse, which carries 3 copies ...
Role of early postnatal nutrition during lactation in offspring metabolic health programming
Childhood obesity and overweight can often cause severe complications, including hypertension, dyslipidemia, insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease, amongst other disorders. Several ...
Role of EPHA3 in colorectal cancer
Los receptores EPH (receptores de efrina) constituyen la subfamilia más grande de los receptores tirosina quinasas en mamífero. Se unen a las efrinas, ancladas a las membranas celulares mediante un enlace glicosilfosfati ...
Role of EphB receptors in intestinal epithelial cell positioning and colorectal cancer progression
In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ephrin-Bs. Eph-ephrin ...
Role of epigenetic modifications in acute promyelocytic leukemia
Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de ...
The role of FGF21 in the metabolic response to amino acid restriction
Obesity and associated metabolic diseases have reached epidemic proportions, affecting not only high-income countries but also low- and middle-income ones. In this context, the search for therapeutic approaches to treat ...
