Characterization of emerging novel human astrovirus: form bedside to bench 

Vu Cantero, Diem-Lan (Date of defense: 2020-01-20)

Novel human astrovirus (HAstV) are enteric virus belonging to the Astroviridae family and were discovered 10 years ago by high-throughput sequencing. They are divided in two different clades, the HAstV-MLB including 3 ...

Characterization of endothelial cell metabolism under different microenvironmental challenges: exploring therapeutic implications of targeting glycogen degradation 

Jayaraman, Anusha (Date of defense: 2016-07-05)

Angiogenesis is the formation of blood vessels from the pre-existing ones and is required for distributing nutrients and oxygen to the tissues through the blood flow. This process is important for tumour tissues as well, ...

Characterization of Endothelial Cells dysfunction associated to Acute Myocardial Infarction: modulation of metabolic pathways as a new therapeutic approach 

Zodda, Erika (Date of defense: 2019-12-13)

The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated with metabolic ...

Characterization of endothelial to mesenchymal transition induced by Notch 

Frías Hernández, Àlex (Date of defense: 2015-12-10)

Notch activation in aortic endothelial cells (ECs) takes place at embryonic stages during cardiac valve formation and induces an endothelial-to-mesenchymal transition (EndMT). Using aortic ECs, we show here that active ...

Characterization of epigenetic and transcriptional changes in aging and Alzheimer’s disease 

Cosín Tomàs, Marta (Date of defense: 2017-02-28)

Epigenetic changes are currently recognized as part of the aging process and have been implicated in many age-related chronic diseases such as Alzheimer’s disease (AD). The term epigenetics includes a variety of processes ...

Characterization of fluid biomarker profiles in the preclinical stage of the Alzehimer's continuum 

Milà Alomà, Marta (Date of defense: 2022-04-29)

La malaltia d’Alzheimer (MA) està precedida per una llarga etapa preclínica, en la qual es desenvolupa la patologia cerebral en absència de simptomatologia. La identificació acurada d’aquesta fase preclínica, i un millor ...

Characterization of Galectin-1 in Pancreatic Cancer: A sweet target for a bitter disease 

Martínez Bosch, Neus (Date of defense: 2011-09-26)

Pancreatic cancer is nowadays one of the neoplasms with worst prognosis, so research towards the discovery of new molecular targets for therapy and diagnosis is more than urgent. In this direction, we have deeply evaluated ...

Characterization of genetic factors associated with melanoma susceptibility and prognosis 

Potrony Mateu, Míriam (Date of defense: 2018-09-28)

Melanoma is the malignant tumor arising from melanocytes and is the most aggressive of the common skin cancers. Melanoma is the tumor with the highest heritability (58%) and around 10% of cases occur in a familial context. ...

Characterization of graphene oxide obtained from modifications of Hummers' method and its application for reinforcing textiles 

Aixart Forés, Jordi (Date of defense: 2021-11-26)

L’òxid de grafè (GO) és un nou nanomaterial relacionat amb el grafè. La seva popularitat es basa en la facilitat de producció, l’escalabilitat i la seva afinitat amb l’aigua, el que facilita el seu maneig i aplicació. La ...

Characterization of heart failure with preserved ejection fraction in the outpatient setting: improvement in prognosis assessment and applicability of new echocardiographic techniques 

Sanchis Ruiz, Laura (Date of defense: 2016-10-20)

Heart failure with preserved left ventricular ejection fraction (HFPEF) is the most prevalent type of heart failure (HF) in the outpatient setting. Left ventricular ejection fraction values (considered as a surrogate of ...

Characterization of hydrological processes in a Mediterranean mountain research catchment by combining distributed hydrological measurements and environmental tracers 

Roig Planasdemunt, Maria (Date of defense: 2016-06-27)

The main objective of this thesis is to characterize hydrological processes in a Mediterranean mountain catchment, by combining distributed hydrological measurements and environmental tracers in order to improve the ...

Characterization of immune responses to porcine circovirus type 2 (PCV2) infection and vaccination in pigs 

Fort de Puig, Maria (Date of defense: 2009-07-17)

El Circovirus porcí tipus 2 (PCV2) és l'agent causal de la circovirosi porcina (CP), una malaltia multifactorial que afecta porcs en fases de transició i engreix i que causa importants pèrdues econòmiques a la indústria ...

Characterization of information and causality measures for the study of neuronal data 

Chicharro Raventós, Daniel (Date of defense: 2011-04-07)

We study two methods of data analysis which are common tools for the analysis of neuronal data. In particular, we examine how causal interactions between brain regions can be investigated using time series reflecting the ...

Characterization of intracellular protein aggregates 

Villar i Piqué, Anna (Date of defense: 2013-06-12)

Durant les últimes dècades, l'agregació de proteïnes ha esdevingut un tema d’investigació molt dinàmic que s'estén transversalment per diferents camps de recerca, incloent la bioquímica, la biotecnologia, la biomedicina i ...

Characterization of iron deficiency in COPD patiens: implications in exercise tolerance and redox balance in muscle and systemic compartments 

Pérez Peiró, Maria (Date of defense: 2023-03-28)

Chronic obstructive pulmonary disease (COPD) patients may present different types of systemic manifestations. Iron deficiency (ID) (Fe, an essential nutritional element) is common and can negatively affect exercise tolerance ...

Characterization of Latent autoimmune diabetes in adults in a region of India 

Kumar, Alok (Date of defense: 2018-05-30)

Introducción: Una proporción de pacientes con diabetes de la edad adulta, que inicialmente no requieren insulina, presentan autoanticuerpos contra la decarboxilasa del ácido glutámico (GADA) en el suero y diferencias ...

Characterization of mechanisms underlying neuronal survival and plasticity in Huntington's disease 

Anglada Huguet, Marta (Date of defense: 2013-07-22)

Huntington’s disease is a progressive neurodegenerative disorder caused by the expansion of a CAG tract in the exon-1 of the huntingtin gene. Mutant huntingtin induces a large amount of toxic effects that trigger cell ...

Characterization of microcellular plastics for weight reduction in automotive interior parts 

Gómez Monterde, Javier (Date of defense: 2017-02-17)

The present PhD thesis is framed within the Industrial Doctorate Plan promoted by the Generalitat de Catalunya and has been developed in cooperation between the Universitat Politècnica de Catalunya-BarcelonaTech, the Centre ...

Characterization of mixing and spreading in heterogeneous media 

Zavala Sánchez, Gabriela Vanessa (Date of defense: 2008-07-02)

Characterization of molecular mechanisms of acquired resistance to Trastuzumab in gastric cancer 

Sampera Borràs, Aïda (Date of defense: 2018-11-20)

The HER2 receptor is overexpressed in 7-34% of gastric cancer (GC) tumors, being a potential therapeutic target. Trastuzumab, an anti-HER2 monoclonal antibody, in combination with platinum therapy was approved in 2010 as ...