Browsing by Title

Characterization of SF3B1 mutation in chronic lymphocytic leukemia and the role of new splicing modulators

López Oreja, Irene (Date of defense: 2022-03-01)

Mutations in Splicing Factor 3b Subunit 1(SF3B1) are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are associated with worse disease prognosis. SF3B1 is involved in pre-mRNA splicing and is the ...

Characterization of simple and complex genomic structural variation : a study of human populations and leukaemia

Bassaganyas Bars, Laia (Date of defense: 2013-09-20)

Over the last ten years, improvements in molecular techniques and the arrival of the next-generation sequencing technologies have revealed a large amount of structural variation (SV) in the human genome. Consequently, there ...

Characterization of snail1 and pten transcriptional regulation by snail1: New insights into epithelial-to-mesenchymal transition and cell resistance to apoptosis

Escrivà Izquierdo, María (Date of defense: 2008-06-20)

The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are forced to acquire a ...

Characterization of Spatial Heterogeneity in Groundwater Applications

Trinchero, Paolo (Date of defense: 2009-02-20)

La heterogeneidad es una característica saliente de cada formación geológica natural. En las últimas décadas un gran número de trabajos se han centrado en estudiar la influencia de la heterogeneidad en los problemas de ...

Characterization of synthetic lethality between MYC activation and splicing inhibition in an immortalized cell line : roles of alternative splicing

Herrero Vicente, Jorge (Date of defense: 2024-02-26)

Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...

Characterization of the 5-HT(7) receptor as a new therapeutic target for the treatment of pain

Brenchat Barberà, Àlex (Date of defense: 2012-03-26)

The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project at Esteve, focused ...

Characterization of the Armcx/Almc10 gene family function in mitochondrial dynamics and neural development

Mirra, Serena (Date of defense: 2013-07-26)

The Armcx gene cluster arose by retrotransposition from a single Arm-containing gene (Armc10), and by subsequent short-range tandem duplications of a rapidly evolving region of the Eutherian X chromosome. In this work we ...

Characterization of the biological effects of natural compounds against inflammation, metabolic syndrome and cancer

Tomás Hernández, Sara (Date of defense: 2017-09-07)

Els productes naturals han sigut àmpliament utilitzats per al tractament i prevenció de moltes malalties. L’objectiu principal d’aquesta tesi ha estat caracteritzar compostos naturals bioactius que podrien ser utilitzats ...

Characterization of the circadian clock function in the control of cell cycle progression to modulate growth in Arabidopsis thaliana

Fung Uceda, Jorge Alberto (Date of defense: 2018-10-26)

La función circadiana es esencial para el crecimiento y adaptación de las plantas a su entorno. La maquinaria molecular responsable de la generación de ritmos circadianos está basada en la expresión rítmica de genes cuyo ...

Characterization of the DNA methylation patterns of chemosensitive and chemoresistant human cancer cells: Biological and clinical impact

Moutinho, Cátia (Date of defense: 2014-05-23)

Although chemotherapeutic drugs are widely used in order to improve the cancer outcome, drug resistance remain the most unpredictable factor affecting chemotherapy and a major impediment to successful patient’s treatment. ...

Characterization of the enzymes involved in the diolsynthase pathway in Pseudomonas aeruginosa

Shoja Chaghervand, Shirin (Date of defense: 2019-07-12)

In 2015 our research group described, in P. aeruginosa, the oleate-diol synthase system which consists of two sequentially and independently enzymatic reactions: 10S-Dioxygenase (10-DOX) (PA2077) used oleic acid (as preferred ...

Characterization of the fas death receptor antagonist in the nervous system, lifeguard (LFG)

Urresti Ibáñez, Jorge (Date of defense: 2014-09-28)

La activación del Receptor de Muerte Fas, también llamado APO-1 o CD95, da lugar a la formación del Death Inducing Signaling Complex (DISC). Este complejo proteico contiene FADD y caspasa-8, entre otras proteínas, y causa ...

Characterization of the functional connection between the BROMODOMAIN and EXTRATERMINAL DOMAIN PROTEIN 9 (BET9) and the circadian clock in Arabidopsis thaliana

Maric, Aida (Date of defense: 2021-11-05)

The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing organisms to anticipate ...