Now showing items 5633-5652 of 11001

    Identificación y prevalencia de factores precipitantes de insuficiencia cardiaca aguda en los servicios de urgencias españoles y su relación con el pronóstico a corto y medio plazo 

    Aguirre Tejedo, Alfons (Date of defense: 2018-03-23)

    Introducción. Hay pocos estudios que analicen el papel que juegan los factores precipitantes (FP) en el manejo de la insuficiencia cardiaca aguda (ICA). Los datos respecto a la epidemiología de los FP y su relación con el ...

    Identificación, biogénesis y función de Dominios ER-HMGR de retículo endoplasmático en Arabidopsis thaliana 

    Grados Torrez, Ricardo Enrique (Date of defense: 2014-07-17)

    La sobreexpresión del dominio de membrana de la Hidroximetil glutaril CoA reductasa (HMGR) en Arabidopsis thaliana desencadena la formación de agregados vesiculares de retículo endoplasmático (RE), esta capacidad morfogénica ...

    Identification and characterisation of transcriptional regulators through proximity interaction mapping in two distinct systems 

    Lewis, Michael (Date of defense: 2022-11-11)

    [eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different transcriptional ...

    Identification and characterization of Adenosine A(2A) heteromers in the CNS = Identificació i caracterització d’heteròmers d’Adenosina A2A al SNC 

    Brugarolas Campillos, Marc (Date of defense: 2013-12-20)

    The aims of this thesis are: Aim 1. The involvement of A(1)R-A(2A)R heteromer in glial cells and its study at a molecular level. Aim 2. To find evidence for allosteric interactions between partner receptors in the ...

    Identification and characterization of cystinuria modulating genes: L-Ergothioneine as a potential treatment for preventing cystine lithiasis 

    Mayayo Vallverdú, Clara (Date of defense: 2021-11-29)

    [eng] Cystinuria, with a worldwide prevalence estimated at 1:7000, is a rare inherited disease characterized by urine hyperexcretion of cystine and dibasic amino acids. Its clinical manifestation is cystine lithiasis in ...

    Identification and characterization of disease-related copy number variations (CNVs) by high-dense SNP oligonucleotide microarrays 

    Rivera Brugués, Núria (Date of defense: 2012-03-20)

    Genomic microarray analysis is rapidly replacing conventional chromosome analysis by molecular karyotyping due to the significant increase in the power to detect causative CNVs. Here, we extensively validated the HumanHap550 ...

    Identification and characterization of new complex patterns of structural DNA and RNA alterations in cancer 

    Delgado Serrano, Luisa Fernanda (Date of defense: 2021-12-02)

    Human cancer arises as a result of genomic alterations that transform cells and make them to grow without control and to pathological levels. The characterization of such genomic changes has enabled understanding tumor ...

    Identification and characterization of non-coding genomic variations associated to cancer diseases 

    González Rosado, Santiago (Date of defense: 2016-04-28)

    The genetic and molecular bases of most of the human diseases have become one of the main goals of the human biology in the last decades. To be able to unveil the genetic variations and the affected cellular processes ...

    Identification and Fate of Known and Unknown Transformation Products of Pharmaceuticals in the Aquatic System 

    Žonja, Božo (Date of defense: 2017-02-01)

    Pharmaceuticals which are used worldwide are designed to facilitate the life for the human society and have an important role in treatment and prevention of disease for both humans and animals. They are ubiquitous in the ...

    Identification and functional analysis of molecular mechanisms involved in the latency of ER positive breast cancer 

    Henryka Gawrzak, Sylwia (Date of defense: 2016-11-23)

    Breast cancer is the most frequently diagnosed cancer and remains the second leading cause of death among women in Europe and United States. In this malignancy, metastasis remains to be an incurable condition, and therefore ...

    Identification and functional analysis of new factors that mediate tramtrack's function during Drosophila tracheal system development / Identificación y análisis funcional de nuevos factores que median la función de tramtrack durante el desarrollo del sistema traqueal de Drosophila 

    Rotstein Bajo, Bárbara (Date of defense: 2013-03-22)

    A stereotyped tubular epithelial network forms many of our bodies’ organs and, defects in the formation of these tubules often leads to organ failure. My Thesis project aims to further understand the mechanisms underling ...

    Identification and functional characterization of genetic loci involved in osteoporosis and atypical femoral fracture 

    Roca Ayats, Neus (Date of defense: 2019-11-18)

    Osteoporosis is a complex disease, determined by genetic and environmental factors, characterized by a low bone mass and microarchitectural deterioration of bone tissue, with a consequent decrease of bone strength and ...

    Identification and functional characterization of P1N-PISPO, a new gene product present in sweet potato potyviruses 

    Mingot Martí, Ares (Date of defense: 2016-05-31)

    Sweet potato feathery mottle virus (SPFMV) (Potyvirus genus, Potyviridae family) causes important yield losses in sweet potato crops, in particular in co-infections with the unrelated crinivirus Sweet potato chlorotic stunt ...

    Identification of a risk transcriptome and proteome in Parkinson’s disease, Dementia with Lewy bodies and rapidly progressive Dementia with Lewy bodies 

    Garcia Esparcia, Paula (Date of defense: 2016-12-02)

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by movement impairment, or parkinsonism, for which there is still no cure. The manifest clinical signs result from neuronal loss of more ...

    Identification of deubiquitinating enzyme genes relevant for the regulation of retina-specific genes 

    Esquerdo Barragan, Mariona (Date of defense: 2017-05-26)

    Protein post-translational modifications are regulatory mechanisms that cells use in response to intra- and extracellular signals. These signals modulate a panoply of conjugating enzymes that modify proteins post-translationally ...

    Identification of Genetic Susceptibility Factors for Fibromyalgia / Identificació de factors de susceptibilitat genètica per a fibromiàlgia 

    Docampo Martínez, Elisa (Date of defense: 2013-04-16)

    Fibromyalgia (FM) is a highly disabling syndrome defined by a low pain threshold and a permanent state of pain. Widespread pain is accompanied by a constellation of symptoms such as fatigue, sleep disturbances and cognitive ...

    Identification of immune biomarkers for use in early HIV detection and monitoring in sub-Saharan Africa = Identificación de biomarcadores de respuesta inmunitaria para la detección temprana y monitorización del VIH en África sub-Sahariana 

    Pastor Palomo, Lucía (Date of defense: 2017-10-11)

    BACKGROUND AND RATIONALE Acute HIV infection (AHI) is the period between the acquisition of the human immunodeficiency virus (HIV) and the development of HIV-specific antibodies that define seroconversion. AHI is ...

    Identification of mechanisms of acquired resistance to taxanes in triple negative breast cancer using patient-derived xenografts: a step closer to clinics 

    Gómez Miragaya, Jorge (Date of defense: 2018-04-27)

    Chemotherapy is a general treatment for most breast tumors and depending on breast cancer subtype combination with targeted anti-hormonal or anti-HER2 therapy is conducted. Taxane-based regimens constitute the most common ...

    Identification of new candidate genes for germline predisposition to familial colorectal cancer using somatic mutational profiling 

    Díaz Gay, Marcos (Date of defense: 2019-11-25)

    Colorectal cancer (CRC) is one of the malignant neoplasms with higher incidence and mortality in Spain, Europe and worldwide. As a complex disease, both environmental and genetic factors influence CRC predisposition. Up ...

    Identification of novel mechanisms in human breast cancer lung metastasis and chemoresistance 

    Arenas Lahuerta, Enrique Javier (Date of defense: 2017-04-07)

    Breast Cancer (BC) is one of the major causes of cancer deaths in women. BC is a heterogeneous disease, and within the heterogeneity of the tumor, Tumor-Initiating Cells (TICs) have been reported as important drivers in ...