Universitat de Barcelona
Mostrando ítems 5243-5262 de 11082
P. vivax is the most widespread malaria, it accounts for 25-40% of the global disease burden and it is estimated that causes from 132 to 391 million clinical cases each year. It is amply accepted that P. vivax do not ...
Plant growth and productivity are compromised by environmental stresses such as pathogens, extreme temperatures, drought and high salinity. Being sessile organisms, plants had to develop different physiologic and biochemical ...
Biodiversity patterns are results of ecological and evolutionary processes. Understanding the forces shaping biodiversity patterns help to predict the responses of ecosystems to environmental change. Considering the role ...
"R. solanacearum" is a devastating bacterial pathogen that infects "Solanaceae" spp. such as tomato, eggplant or banana. A functional T3SS is required for virulence and more than 70 putative effectors have been described, ...
Single amino acid variants (SAVs) are one of the main causes of Mendelian disorders, and play an important role in the development of many complex diseases. At the same time, they are the most common kind of variation ...
[eng] This thesis focuses on the functional design and preparation of different kind of nanocomposites and their applications in energy conversion and storage technologies, particular in OER, HER, H2O2ER and LSBs. For the ...
La ciencia básica ha de engarzarse con las necesidades sociales. Así, nuestro laboratorio esta involucrado en identificar genes específicamente modulados durante el proceso de cicatrización mediante estudios transcriptómicos ...
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
The present thesis has established a new and state of the art mammalian protein expression system at the laboratory which has then contributed with high-yield expression for the purification and crystallization of three ...
The work developed during this PhD has embraced several topics that I divide in three blocks. Each block contains two chapters in this dissertation. Additionally, a general introduction of the different topics is provided ...
Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological ...
After germination in darkness, Arabidopsis seedlings follow a dark specific developmental pattern called skotomorphogenesis or etiolation, characterized because the plant develops long hypocotyls together with a closed ...
Plasma Polymerization is a novel technique for the preparation of polymer-like thin film coatings at low temperatures onto almost any type of substrates: plastic, metal, semiconductors, wood, textile fibers or membranes, ...
Freshwater degradation has been largely attributed to excess nutrient concentrations of anthropogenic origin. Freshwater degradation in combination with water scarcity are the reason of severe stress on water resources ...
Macrophages require presence of M-CSF to survive and proliferate. Incubation of bone marrow macrophages with soluble factors (LPS or IFN-gamma) or insoluble factors such as extracellular matrix proteins (Decorin, FN) ...
Glucocorticoids (GC) induce cell cycle arrest and apoptosis in different cell types and therefore are widely used to treat a variety of diseases including autoimmune disorders and cancer. This effect is mediated by the GC ...
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this process: cyclin- ...
