Universitat Pompeu Fabra
Now showing items 756-775 of 3213
Dosage compensation is a mechanism that equalizes the expression of X-linked genes in those organisms in which males and females differ in the number of X chromosomes. In Drosophila melanogaster, dosage compensation is ...
Adolescence is a critical developmental period in which the brain emerges from an immature state to adulthood. This process of brain development is associated to greater cognitive capacity but also to altered emotional ...
The explosion of reductionist approaches at the end of the XXth century allowed for fast and high-throughput data collection in pharmaceutical industry, but did not deliver the expected gain in drug discovery performance. ...
This thesis adopts DSGE and PVAR models to examine three questions in macroeconomics. The first chapter singles out some pitfalls that DSGE models face when a fraction of rule-of-thumb consumers is assumed in order to ...
Durante el desarrollo del oído interno, Notch presenta dos modos de funcionamiento: inducción lateral, que se asocia con la especificación prosensorial, e inhibición lateral, asociada a la determinación de las células ...
Polycomblike proteins (PCLs) have been shown to regulate Polycomb Repressive Complex 2 (PRC2) by enhancing its catalytic activity and guiding PRC2 to its target genes in embryonic stem cells. However, little is known about ...
Positron emission tomography (PET) is a functional imaging method that allows studying physiological, biochemical or pharmacological processes in vivo. PET is being used in both research and clinical practice. In the brain, ...
Les duplicacions segmentàries (DSs), o també anomenades duplicons o Low copy Repeats (LCRs), són regions de coma mínim 1 kb amb un alt nivell d'identitat (>90%), que estan presents almenys dues vegades en el genoma. La ...
Bacterial proliferation has been studied for more than 100 years, but our knowledge of the mechanisms that control its dynamical aspects is still very limited. In this Thesis we have studied, at both singlecell and ...
Living beings strive to survive and reproduce. To do so they need to monitor and adapt to a dynamic environment, taking advantage of the opportunities and dodging the threats that they may encounter. This thesis is devoted ...
Across metazoans, minimal in vitro systems from embryonic stem cells (ESCs) recapitulate the establishment of a body plan, particularly the anteroposterior (AP) axis. In contrast to actual embryos that generally require ...
This thesis is about development and its study from a theoretical point of view, with special interest in how to describe development as a dynamical systems' problem. The thesis digs into four directions embedded in this ...
Every animal on our planet wanders around when looking for something. Whether it is in search of food, a mate, or home, navigation is one of the most performed cognitive behaviors in Nature. Nevertheless, our understanding ...
Esta tesis estudia dos diferentes dinámicas de intercambio de mensajes entre unidades estocásticas.<br/>Primero, analizamos un conjunto de neuronas estocásticas tipo integración - y - disparo con integración sin pérdidas, ...
El receptor de la progesterona és un regulador clau per la proliferació de les cèl·lules de càncer de mama dependents d’hormona. El mecanisme d’acció del PR ha tingut un paper important en la resolució del mecanisme molecular ...
Fluctuations are fundamental for living organisms. They arguably result from interactions with the complex, and unpredictable environment, and can often be manifested as temporal variability. The cell must continually ...
The broad objective of this thesis is to study the patterns of objective and subjective well-being among the immigrants in Europe. The main part of the thesis consists of three single-authored empirical chapters. The first ...
En aquesta tesi he investigat diversos camps de la biologia que podrien englobar-se en la disciplina general dels sistemes no lineals de replicadors. Els treballs presentats en aquesta tesis investiguen diversos fenomens ...
DYRK (dual-specificity tyrosine-regulated kinases) is an evolutionary conserved family of protein kinases involved in the regulation of cellular processes, such as proliferation and survival, which play pivotal role in ...
Worldwide, 10% of the population has dyslexia, a cognitive disability that reduces readability and comprehension of written information. The goal of this thesis is to make text more accessible for people with dyslexia by ...
