López Arribillaga, Erika (Date of defense: 2016-06-17)
Wnt/β-catenin and Notch signalling cooperate in regulating the transcription of various genes specifically in the small intestinal stem and progenitor cell compartments. We characterized Bmi1 functionally ...
Trincado Alonso, Juan Luis (Date of defense: 2019-01-28)
The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main ...
Ledda, Alice (Date of defense: 2011-05-06)
Els microsat el lits s on seq u encies d'ADN formades per repeticions en t andem de motius curts. Les curtes seq u encies repetides en t andem s on ubiq ues en els genomes dels eucariotes, tant en les ...
Geers, Adrianus Johannes (Date of defense: 2015-01-12)
Cerebral aneurysms are localized, pathological dilatations of cerebral arteries. Their rupture causes a subarachnoid hemorrhage and is associated with high rates of morbidity and mortality. Over the ...
Alcoberro Llivina, Carina (Date of defense: 2015-01-14)
The primary objective of the present work is to contextualise the so-called national constitutional identity clause enshrined in current Article 4(2) TEU and, by doing so, to provide some guidance to ...
Silva Blanc, Luisina (Date of defense: 2019-12-05)
Attention toward textile production and clothing consumption in Spanish Latin American increased during the end of the colonial period and was reflected in new regulations, newspaper articles, tighter ...
Puighermanal Puigvert, Emma (Date of defense: 2011-09-27)
The endocannabinoid system is an endogenous neuromodulatory system that regulates a plethora of physiological functions, including the control of movement, memory, anxiety, and pain, among others. ...
Campos Mata, Leire de (Date of defense: 2019-12-18)
The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation. In this thesis we uncover an unanticipated ...
Dalmases Massegú, Alba (Date of defense: 2012-06-22)
EGFR is a transmembrane tyrosine kinase receptor from the HER family which, upon ligand stimulation, activates different signaling pathways involved in tumorogenesis. EGFR can be targeted by monoclonal ...
Messaggi-Sartor, Monique (Date of defense: 2017-04-07)
Respiratory muscle dysfunction is a clinical condition that may be present in both respiratory and non-respiratory diseases. This impairment of muscle function can have a negative effect on clinical ...