Iannone, Camilla (Date of defense: 2014-05-23)
Intron removal is a necessary step for expression of most genes in higher eukaryotes, and alternative splice selection is a highly regulated mechanism that endows a single gene with the possibility to ...
Benisty, Hannah (Date of defense: 2019-12-13)
The RAS oncogenes KRAS, NRAS and HRAS are mutated in one third of human cancers where they exhibit different mutation patterns. A potential factor contributing to this mutation bias is the variation ...
García Santamarina, Sarela (Date of defense: 2013-06-14)
Oxidation of specific cysteines in proteins by hydrogen peroxide (H2O2) is a cellular mechanism that triggers signalling pathways, such as the antioxidant responses in microbial systems. However, H2O2 ...
Padró i Jové, Mercè (Date of defense: 2011-03-28)
Alterations in the expression of carbohydrates and the enzymes involved in their synthesis (glycosidases and glycosyltransferases) can be considered as universal feature of malignant transformation. ...
Viñas Castells, Rosa (Date of defense: 2013-05-24)
Epithelial to mesenchymal transition (EMT) is a process by which epithelial cells acquire a mesenchymal phenotype. It is characterized by the down-regulation of the adherens junction protein E-cadherin, ...
Fornés Crespo, Oriol (Date of defense: 2015-01-21)
Protein-DNA interactions are indispensable players in the daily activities of cells. DNA-binding proteins regulate gene expression and are responsible of DNA replication, packaging, repair and recombination. ...
Çavusoglu, Kader (Date of defense: 2013-06-07)
This project was carried out in the Cell Signaling Research Group headed by Dr. Carme Caelles at IRB Barcelona. As a part of the research-line that deals with physiological and pharmacological ...
Battola, Andrea (Date of defense: 2017-12-12)
Problemes en la replicació de l’ADN, condensació o de-catenació generen ponts anafàsics al punt de divisió, que en molts casos provoquen inestabilitat genòmica. La cèl·lula respon a aquest problema ...
Jiménez-Castells, Carmen (Date of defense: 2010-12-20)
Carbohydrate-binding proteins of non-immunological origin -lectins- have been recognized over the last decades as decisive players in numerous biological processes, ranging from cellcell communication, ...
Martínez Høyer, Sergio (Date of defense: 2012-10-11)
The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators ...