Alberdi Ibarzabal, Maria (Date of defense: 2015-07-24)
CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described ...
Tejedor Vaquero, Sonia (Date of defense: 2018-03-16)
Glucose is a key nutrient for T cells. Despite that T cell activation is impaired when they are deprived of glucose, it has also been shown that T effector responses can be elicited in vivo in glucose-poor ...
Traveset Martínez, Laia (Date of defense: 2020-10-30)
Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to ...
Drews-Elger, Katherine (Date of defense: 2008-11-07)
The transcription factor NFAT5/TonEBP belongs to the Rel family, which also comprises NF ÛB and NFATc proteins. NFAT5 only shares structural and functional homology with other Rel family members at the ...
Huerga Encabo, Hector (Date of defense: 2018-11-16)
Ortells Campos, Mª Carmen (Date of defense: 2012-07-26)
Adaptive responses allow cells to maintain their growth as well as their proliferative potential under diverse stress conditions. It is known that, growth and proliferation can be suppressed by intense ...
Colomer-Lahiguera, Sara (Date of defense: 2015-11-19)
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10 15% of pediatric ALL. The oncogenic transformation of T-cell precursors is driven by a broad spectrum of genetic abnormalities. We have confirmed ...
Higuera González, Laura (Date of defense: 2021-10-01)
Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network ...
Minguillón Pedreño, Jordi (Date of defense: 2008-01-04)
El NFAT5 es un factor de transcripción de la familia Rel, la cual incluye a los NFATc y los NF-[kappa]B. Hasta ahora, el NFAT5 había sido caracterizado principalmente como un factor de respuesta a estrés ...
Val Casals, Maria (Date of defense: 2020-07-09)
Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària ...