Alba Castellón, Lorena (Date of defense: 2016-02-17)
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that ...
García Parra, Jetzabel (Date of defense: 2012-06-21)
Breast cancer is the main cause of cancer death in women. Improved treatments, prevention programs and earlier detection are reducing the rate of death; however, there is still a high percentage of ...
Pérez Llamas, Christian (Date of defense: 2015-12-18)
Given the complexity and heterogeneity of cancer, the development of new high-throughput wide-genome technologies has open new possibilities for its study. Several projects around the globe are ...
Sánchez Osuna, María (Date of defense: 2014-12-19)
Glioblastoma multiforme, one of the most aggressive and lethal tumors, is characterized by a high apoptosis resistance. This doctoral thesis addresses the biochemical behavior of diverse glioblastoma ...
Stanisavljević, Jelena (Date of defense: 2014-07-17)
Carcinomas initiate their invasion hijacking the innate plasticity of both epithelial cells and mesenchymal stromal cells in a reciprocal way. Chemical and mechanical dialogue between stromal fibroblasts ...
Frigola Rissech, Joan (Date of defense: 2020-03-13)
The rate at which mutations accumulate along the genome is not uniform but influenced by factors such as chromatin compactness, replication time or transcription. Most of these factors create mutational ...
Trincado Alonso, Juan Luis (Date of defense: 2019-01-28)
The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main ...
Domínguez Rodríguez, Diana (Date of defense: 2021-05-04)
La metàstasis és responsable del 90% de les morts per càncer, demostrant l’existent manca de coneixement en relació als seus mecanismes moleculars. Investigacions anteriors del nostre laboratori han ...
Besedina, Elizaveta (Date of defense: 2023-05-12)
Determinar qué genes están bajo selección durante la evolución del cáncer puede explicar cómo se forman y progresan los tumores, y sugerir nuevos objetivos terapéuticos. Sin embargo, la detección de ...
Ramírez Cuéllar, Angélica Julieta (Date of defense: 2022-05-12)
In this Thesis we report the successful growth of hormone responsive T47D cells as 3D spheroids in Matrigel mimicking the ECM. A detailed characterization by using a genome-wide approach of the main ...