Pazo Pelegrí, Esther (Date of defense: 2021-07-15)
At the end of G1 phase, cells have to decide between continue proliferation or remain in a quiescent state (G0). This decision point, known as “Start” in yeast and “Restriction Point” in metazoans, marks ...
Malapeira Argilaga, Jordi (Date of defense: 2006-11-30)
Esta tesis doctoral consiste en la caracterización de la ciclina meiótica Rem1, de Schizosaccharomyces pombe. En este trabajo se analizó, inicialmente, el patrón de transcripción y expresión de rem1 ...
Borao Arriazu, Sonia (Date of defense: 2022-07-22)
Schizosaccharomyces pombe initiates sexual development under nitrogen starvation, changing the transcription patterns of many genes to allow sexual differentiation. MBF transcription factor recognize ...
Ivanova, Tsvetomira Georgieva (Date of defense: 2012-11-30)
DNA damage is an ongoing threat to both the ability of the cell to faithfully transmit genetic information to its offspring as well as to its own survival. In order to maintain genomic integrity, ...
González Medina, Alberto (Date of defense: 2019-03-01)
The control of proper progression of eukaryotic cell cycle is essential if cells want to continue proliferating appropriately, and it is a conserve feature from yeast to human cells. One of the most ...
Gómez Escoda, Blanca (Date of defense: 2010-11-26)
When DNA replication is challenged, cells activate a DNA synthesis checkpoint blocking cell cycle progression until they are able to overcome the replication defects. In fission yeast, Cds1 is the ...
Knezevic, Iva (Date of defense: 2015-07-17)
In eukaryotic cells a key regulatory step of cell cycle occurs in late G1, which has been termed “Start” in yeast cells. At this point, cells determine whether they will go to through a new round of ...
Moldón Vara, Alberto (Date of defense: 2008-10-17)
The meiotic cell cycle is modified from the mitotic cell cycle by having a premeiotic S phase which leads to high levels of recombination, two rounds of nuclear division with no intervening DNA synthesis, ...
Salat Canela, Clàudia (Date of defense: 2020-09-30)
Living organisms must respond to changes in their environment in order to overcome stress situations. In Schizosaccharomyces pombe, Sty1 MAP kinase is required to survive to a wide range of environmental ...