Cortina Duran, Carme (Date of defense: 2009-09-10)
In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ...
Whissell, Gavin (Date of defense: 2013-12-03)
The recent discovery that intestinal adenomas are built on a stem cell hierarchy has raised great interest in understanding the signals that maintain tumor stem cells. We unveiled the existence of a ...
Morral Martínez, Clara (Date of defense: 2017-07-17)
El càncer de colon es caracteritza per presentar una composició cel·lular heterogènia en la qual només un subgrup de cèl·lules retenen la capacitat de contribuir en el manteniment i creixement del tumor. ...
Montagni, Elisa (Date of defense: 2015-11-09)
The first chapter identifies the transcription factor GATA6 as negative regulator of a transcriptional circuit dedicated to prevent the expansion of Adenoma Stem Cells (AdSCs) during the onset of ...
Barriga de Vicente, Francisco Martín (Date of defense: 2013-11-28)
The first chapter of this thesis describes the study of intestinal stem cells (ISCs) and their relationship to colon cancer. We describe the transcriptional landscape of intestinal epithelial populations ...