Now showing items 315-334 of 456

    Neural network mechanisms of working memory interference 

    Barbosa, João Moura (Date of defense: 2019-05-24)

    Our ability to memorize is at the core of our cognitive abilities. How could we effectively make decisions without considering memories of previous experiences? Broadly, our memories can be divided in two categories: ...

    Neural Stem Cell Factors as Important Players in Glioblastoma Pathogenesis 

    Moreno Monasterio, Marta (Date of defense: 2015-02-18)

    The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, which might be ...

    Neurocirurgia Pediàtrica Funcional assistida per Braç Robòtic Neuromate®. Precisió i resultats clínics inicials 

    Candela Cantó, Santiago Antonio (Date of defense: 2019-01-16)

    ANTECEDENTS: Per a l’adequat diagnòstic i/o tractament dels pacients amb epilèpsia refractària o trastorns del moviment es requereix la implantació d’elèctrodes cerebrals en alguns casos seleccionats. HIPÒTESIS: El robot ...

    Neuroimaging and executive function in dyskinetic cerebral palsy 

    Laporta-Hoyos, Olga (Date of defense: 2018-10-08)

    INTRODUCCIÓN: La parálisis cerebral es una de las causas más frecuentes de discapacidad física en niños y supone una condición que persiste a lo largo de la vida (Krageloh-Mann & Cans, 2009). Concretamente, la prevalencia ...

    Neurological syndromes associated with antibodies against the glutamic acid decarboxylase (GAD) 

    Ariño Rodríguez, Helena (Date of defense: 2017-03-28)

    This thesis focuses on antibodies against the glutamic acid decarboxylase (GAD-ab) in neurological disorders. GAD-ab were first identified in 1988 in the serum and CSF from one patient with stiff-person syndrome (SPS) and ...

    Neuronal basis of auditory adaptation and temporal discrimination in the auditory cortex of the awake freely moving rat 

    Abolafia Moya, Juan Manuel (Date of defense: 2011-02-02)

    La adaptación que ocurre en el sistema auditivo es un fenónemo que todos experimentamos cuando dejamos de oir sonidos irrelevantes, constantes o incluso molestos. La adaptación para sonidos conocidos aumenta también la ...

    Neuropilin 2 role in the regulation of disseminated tumour cells dormancy and metastasis in breast and head and neck cancer 

    Recalde-Percaz, Leire (Date of defense: 2021-06-30)

    Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with more than 90% of ...

    New experimental approaches to study the relevance of the TGF-β and EGFR signalling during liver tumorigenesis 

    Caballero Díaz, Daniel (Date of defense: 2018-02-09)

    Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, where pro-apoptotic ...

    New genes and pathways implicated in Rett syndrome: considerations and future applications 

    Lucariello, Mario (Date of defense: 2017-03-16)

    STUDY I HYPOTHESIS Genetic alterations have already been recognized as major etiological factors for ASD and ID, of which RTT is an example. In addition to the contribution of polymorphic variants that confer low or ...

    New insights into the colorectal carcinogenesis: from early precursor lesions to the role of aneuploidy 

    Quintanilla Leo, Isabel (Date of defense: 2017-07-20)

    Colorectal cancer (CRC) is one of the most frequent malignancies worldwide and it is considered an important healthcare problem. Moreover, colorectal carcinogenesis is a long stepwise process through a known precursor, the ...

    New insights into the crosstalk between the TGF-β and the EGF Receptor pathways during liver regeneration and hepatocarcinogenesis 

    López Luque, Judit (Date of defense: 2016-11-23)

    Transforming growth factor-beta (TGF-β) is an important growth suppressor in hepatocytes, inhibiting proliferation and inducing cell death. However, it also plays a role in other processes such as epithelial-to-mesenchymal ...

    A new mechanism of antimalarial drug resistance regulated at the epigenetic level 

    Mira Martínez, Sofía (Date of defense: 2018-02-23)

    Malaria is responsible of almost half a million deaths every year. Currently, campaigns for the control and elimination of malaria are implemented in malaria endemic areas. However, drug resistance is one of the major ...

    New strategies to optimize treatment for HIV-1 infection 

    Monteiro D'Albuquerque, Polyana (Date of defense: 2015-06-15)

    Antiretroviral therapy has dramatically reduced morbidity and mortality associated with HIV-1 infection and converted AIDS into a manageable chronic disease. During the past 15 years, antiretroviral drugs have become less ...

    New substrates and functions of PP2A-Cdc55 phospatase in the mitotic exit 

    Baró Sastre, Bàrbara (Date of defense: 2013-09-20)

    La sortida de mitosis comprèn tots els processos de la mitosis que van des de la segregació de les cromàtides germanes a l’obtenció de dues cèl·lules filles genèticament idèntiques. A nivell molecular, les cèl·lules inicien ...

    Nuevas aplicaciones de la ultrasonografía endoscópica (USE) en oncología digestiva 

    Alberghina, Nadia (Date of defense: 2018-12-04)

    INTRODUCCIÓN: la ultrasonografía endoscópica (USE) y la punción aspirativa con aguja fina guiada por USE (USE-PAAF) han demostrado su utilidad en gran número de situaciones clínicas durante los últimos 20 años. El hecho ...

    Nuevas estrategias de control postranscripcional en el desarrollo de adenovirus oncolíticos 

    Villanueva Verdejo, Eneko (Date of defense: 2016-03-11)

    El cáncer de páncreas es la cuarta causa de muerte por cáncer en los países industrializados. En 2030, las predicciones señalan que puede pasar a ser la segunda. Pese a la relativa baja incidencia de este tipo de cáncer, ...

    Nuevas estrategias para mejorar la tolerabilidad del tratamiento antirretroviral y disminuir su impacto sobre las comorbilidades 

    Rojas Liévano, Jhon Fredy (Date of defense: 2019-01-24)

    La infección por el virus de la inmunodeficiencia humana (VIH) continúa siendo un problema importante de salud pública mundial. En 2017 aproximadamente 36,9 millones de personas eran portadoras del VIH (incluidos 1,8 ...

    Nuevos factores del hospedador en la fisiopatología y la respuesta al tratamiento antiviral de la infección por el virus de la hepatitis C 

    Fernández Carrillo, Carlos (Date of defense: 2017-02-01)

    La infección por VHC constituye un problema mundial de primer orden, siendo la primera causa de trasplante hepático en todo el mundo. Se trata de un patógeno muy adaptado a humanos, probablemente durante miles de años en ...

    Nuevos instrumentos subjetivos y objetivos para evaluar la fase preclínica de la enfermedad de Alzheimer 

    Mollica, Maria Antonella (Date of defense: 2017-05-05)

    En la última década, frente al fracaso de los tratamientos farmacológicos para detener el proceso patológico de la enfermedad de Alzheimer, la fase preclínica se ha convertido en un importante foco de investigación, puesto ...

    Nuevos marcadores pronósticos derivados de las signaturas del microambiente tumoral en linfoma difuso de células grandes 

    Cardesa Salzmann, Teresa (Date of defense: 2014-01-21)

    La presente tesis incluye dos trabajos: PRIMER TRABAJO High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy Cardesa-Salzmann ...