Segura Martinez, Joana (Date of defense: 2020-11-02)
El empaquetamiento del ADN en fibras de cromatina implica una gran cantidad de deformaciones geométricas de la doble hélice (enrollamiento y superenrollamiento del ADN) y la formación de una jerarquía ...
Mazuelas Gallego, Helena (Date of defense: 2021-01-28)
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the ...
Delgado Serrano, Luisa Fernanda (Date of defense: 2021-12-02)
Human cancer arises as a result of genomic alterations that transform cells and make them to grow without control and to pathological levels. The characterization of such genomic changes has enabled ...
González Rosado, Santiago (Date of defense: 2016-04-28)
The genetic and molecular bases of most of the human diseases have become one of the main goals of the human biology in the last decades. To be able to unveil the genetic variations and the affected ...
Valls Margarit, Jordi (Date of defense: 2021-06-08)
One of the central aims of biology and biomedicine has been the characterisation and understanding of genetic variation across humans, to answer important evolutionary questions and to explain phenotypic ...
Maher, Michael (Date of defense: 2021-05-07)
The role of fatty acids to overcome stress and contribute to disease progression is becoming increasingly evident in haematological diseases. Further, epigenetic factors play an important role in the ...
Cañete Ríos, Manuel (Date of defense: 2020-11-27)
Xenopus laevis oocytes are transcriptionally silent cells that require hormone stimulation for maturing into fecundation-competent eggs. Meiosis resumption underlying oocyte maturation is governed by ...
Rodriguez Fos, Elias (Date of defense: 2020-07-15)
This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the ...
Puerto Plasencia, Marta (Date of defense: 2022-04-01)
It has been previously shown that the Drosophila heterochromatin protein 1c (HP1c) forms a complex with the transcription factors (TF) WOC and ROW, and the extraproteasomal ubiquitin receptor dDsk2. The ...
Garrido Garcia, Alícia (Date of defense: 2022-11-10)
[eng] BACKGROUND: High-risk neuroblastoma (NB) represents a heterogeneous group of tumors, whereby patients can display response to treatment and long-term outcome or develop early progressive, ...