Llorens Marès, Tomàs (Date of defense: 2015-07-28)
The main objective of this PhD dissertation was to unveil the links between biogeochemistry and microbial diversity using metagenomics functional potential as a proxy to connect a mechanistic perspective ...
Catasús Segura, Núria (Date of defense: 2022-05-31)
Neurofibromatosis type 2 (NF2) is an autosomal dominant condition caused by loss of function variants in the NF2 gene. The pathognomonic feature of the disease is the development of bilateral vestibular ...
Muntadas Olivé, Alba (Date of defense: 2015-12-04)
Fisheries management has definitively embraced the Ecosystem Approach to Fisheries (EAF) philosophy and new management policies are incorporating integrative measures that take into account not only ...
Buitrago Ospina, Diana Camila (Date of defense: 2019-12-16)
Understanding the connection between DNA organization in the nucleus, and cell functioning is one of the most intriguing problems in biology. Although many interdisciplinary efforts have been developed ...
Sanz Pérez, Ana (Date of defense: 2021-07-02)
Extensive farmland ecosystems are widespread and biodiversity-rich, yet they face important human pressures since the beginning of agriculture intensification, which is leading them into a severe ...
Lobón García, Irene (Date of defense: 2019-07-26)
Somatic mutations are those that arise after the zygote is formed and are therefore inherited by a fraction of the cells of an individual. Their relevance in certain skin diseases has been known for ...
Moles Fernández, Alejandro (Date of defense: 2022-01-31)
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision ...
Mazuelas Gallego, Helena (Date of defense: 2021-01-28)
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the ...
Meléndez Esteban, Elena (Date of defense: 2022-03-24)
The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables the conversion of differentiated cells into pluripotent stem cells, a process known as “reprogramming”. Methods ...
Delgado Serrano, Luisa Fernanda (Date of defense: 2021-12-02)
Human cancer arises as a result of genomic alterations that transform cells and make them to grow without control and to pathological levels. The characterization of such genomic changes has enabled ...