Sánchez Baizán, Núria (Date of defense: 2023-10-27)
[eng] Epigenetic mechanisms play a vital role in gene expression regulation and phenotype determination. This thesis aimed to comprehensively investigate the transcriptome, the methylome and the influence ...
Bagiński, Błażej Mikołaj (Date of defense: 2022-12-15)
[eng] Tumour progression largely depends on the signalling networks that direct cell viability, growth and dissemination (metastasis). Transforming growth factor beta (TGF-β) and Bone Morphogenetic ...
Mendoza Blanco, Mónica (Date of defense: 2023-11-24)
[eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major ...
Vilar Ribó, Laura (Date of defense: 2023-11-20)
[eng] Substance use disorders (SUDs) are psychiatric disorders characterized by a recurring desire to continue taking a substance regardless of its destructive consequences. The etiology of SUDs is ...
Giroud-Gernetant Deus, Judith (Date of defense: 2023-11-20)
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that ...
Schikora Tamarit, Miquel Àngel (Date of defense: 2023-11-03)
[eng] Fungal infections pose a serious health threat, affecting >1,000 million people and causing ~1.5 million deaths each year. The problem is growing due to insufficient diagnostic and therapeutic ...
Ruiz Serra, Victoria Isabel (Date of defense: 2023-11-08)
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental ...
Doria Belenguer, Sergio (Date of defense: 2023-10-07)
[eng] Advances in capturing technologies have yielded a massive production of large-scale molecular data that describe different aspects of cellular functioning. These data are often modeled as networks, ...
Alonso Parrilla, Lorena (Date of defense: 2023-01-16)
[eng] One of the major and most challenging goals of Biomedicine during the last centuries has been the study of the human biological mechanisms, and its relation with traits and diseases. Particularly, ...
Özkan, Selen (Date of defense: 2023-12-01)
[eng] Precision medicine aims to provide personalized patient care using genetic data. However, interpreting the phenotypic consequences of genetic variants remains a bottleneck in both clinical and ...