Ara mostrant els elements 27-46 de 46
Alea Reyes, María Elisa (Data de defensa: 2017-07-17)
The present thesis is included in the area of Nanomedicine and supramolecular chemistry, focused on the design and preparation of different nano and microtools for delivery, therapy and sensing. Initially, the synthesis ...
Otermin Esteras, Ane (Data de defensa: 2016-11-23)
En esta Tesis doctoral, se ha puesto a punto una ruta sintética para acceder de manera rápida y eficaz, a compuestos policíclicos tipo “cinturón” que contienen dos dobles enlaces C=C casi paralelos y próximos en el espacio. ...
Guignard, Guillaume Michel Pablo (Data de defensa: 2016-06-23)
1. (R)-Phenylglycinol-derived oxazolopiperidone lactams can be converted to enantiopure open-chain amino ester scaffolds by alkaline hydrolysis of the N-Boc 2-piperidones resulting from the reductive cleavage of the ...
Pérez Janer, Ferran (Data de defensa: 2018-06-01)
Among transition metals used in organic chemistry, palladium has greatly contributed to the development of modern organic synthesis. This thesis is focused on the development of novel and efficient methodologies for the ...
Amenta, Arianna (Data de defensa: 2020-03-27)
Transition metal-catalyzed intramolecular C–H insertions of diazo compounds represent one of the most elegant and versatile methods in organic synthesis for the construction of carbocyclic and heterocyclic frameworks. ...
Griñán Ferré, Christian (Data de defensa: 2016-12-12)
Existe una correlación positiva entre el incremento de la esperanza de vida y el aumento de las enfermedades crónicas. Se ha establecido que el envejecimiento es el principal factor de riesgo en la aparición de trastornos ...
Codony Soler, Xavier (Data de defensa: 2022-06-02)
The sigma-1 receptor is a chaperone that is primarily expressed in the mitochondria-associated endoplasmic reticulum (MAM). It was cloned years ago from different tissues of various species and its structure ...
Viñas Simón, Miquel (Data de defensa: 2023-04-14)
[cat] Aquest treball està orientat en l’estudi de nous sistemes heterocíclics nitrogenats amb potencial activitat biològica, concretament, en la recerca de nous antitumorals per inhibició enzimàtica. S’ha descrit la ...
Kühne, Britta Anna (Data de defensa: 2022-10-21)
[eng] Intrauterine growth restriction (IUGR) is defined as a significant reduction on fetal growth rate, resulting in a birth weight below the 10th percentile for the corresponding gestational age (Sharma et al., 2016). ...
Piccichè, Miriam (Data de defensa: 2021-12-10)
Los alcaloides decahidroquinolínicos (DHQs) representan un pequeño grupo de productos naturales aislados mayoritariamente de fuentes animales, ya sean de origen terrestre o de origen marino, y en menor medida de fuentes ...
Rodríguez Arévalo, Sergio (Data de defensa: 2021-11-26)
La síntesis de compuestos orgánicos heterocíclicos permite acceder a un amplio arsenal de compuestos con potencial actividad farmacológica. El presente manuscrito se enmarca en el campo de la química farmacéutica, desarrollando ...
Urbina Teixidor, Aina (Data de defensa: 2020-06-19)
La calispongiolida es un macrólido aislado en el año 2013 a partir de un extracto metanólico de la esponja Callyspongia sp. recogida en la costa de Indonesia. Este producto natural posee una potente actividad citotóxica y ...
Puigoriol Illamola, Dolors (Data de defensa: 2020-09-10)
The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have ...
Calderón i Almendro, Raquel (Data de defensa: 2017-03-14)
Sphingolipids (SLs) are components of eukaryotic cell membranes that in the last 30 years have shown not only a structural role but also be involved in signaling processes and cellular responses. Therefore, the development ...
Bagán Polonio, Andrea (Data de defensa: 2022-09-23)
The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...
Vasilopoulou, Foteini (Data de defensa: 2021-09-21)
The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...
Bosch, Caroline (Data de defensa: 2016-10-21)
This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists ...
Coussanes, Gilhem (Data de defensa: 2016-12-16)
The manuscript of this Doctoral Thesis has been divided into five main parts: a general introduction into the calyciphylline A-type alkaloids followed by three research chapters and conclude by a review about the radical ...
Are, Celeste (Data de defensa: 2018-09-28)
El presente trabajo se centra en los alcaloides del grupo de las madangaminas, un pequeño grupo de alcaloides diaminopentacíclicos, aislados de esponjas marinas pertenecientes al orden Haplosclerida y derivados biogenéticamente ...
Velázquez Chávez, Ana Magdalena (Data de defensa: 2021-11-09)
La enfermedad del hígado graso no alcohólico es una patología sin tratamiento farmacológico específico que posee una alta prevalencia a nivel mundial, cuya etapa inicial se caracteriza por la esteatosis hepática simple. ...