Browsing Departament de Farmacologia, Toxicologia i Química Terapèutica by Subject "615"

Now showing items 21-28 of 28

Preparació i Avaluació Biològica de Nous Sistemes Heterocíclics Nitrogenats

Viñas Simón, Miquel (Date of defense: 2023-04-14)

[cat] Aquest treball està orientat en l’estudi de nous sistemes heterocíclics nitrogenats amb potencial activitat biològica, concretament, en la recerca de nous antitumorals per inhibició enzimàtica. S’ha descrit la ...

Síntesis formal enantioselectiva del macrólido calispongiolida

Urbina Teixidor, Aina (Date of defense: 2020-06-19)

La calispongiolida es un macrólido aislado en el año 2013 a partir de un extracto metanólico de la esponja Callyspongia sp. recogida en la costa de Indonesia. Este producto natural posee una potente actividad citotóxica y ...

Stress influence in neurodegeneration. Unravelling the mechanisms underlying stress response in brain ageing by 11ß-HSD1 inhibition

Puigoriol Illamola, Dolors (Date of defense: 2020-09-10)

The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have ...

Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs

Bagán Polonio, Andrea (Date of defense: 2022-09-23)

The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...

Targeting the I(2) Imidazoline Receptors: the neuroprotective role of selective ligands in Alzheimer’s Disease

Vasilopoulou, Foteini (Date of defense: 2021-09-21)

The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...

Total Synthesis of Phlegmarine Alkaloids

Bosch, Caroline (Date of defense: 2016-10-21)

This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists ...

Toward the Synthesis of Daphniphyllum Alkaloids using Radical Chemistry

Coussanes, Gilhem (Date of defense: 2016-12-16)

The manuscript of this Doctoral Thesis has been divided into five main parts: a general introduction into the calyciphylline A-type alkaloids followed by three research chapters and conclude by a review about the radical ...

Validación de dianas farmacológicas para la prevención y el tratamiento de la hipertrigliceridemia y el hígado graso inducidos por el consumo de fructosa líquida y dieta rica en grasa saturada

Velázquez Chávez, Ana Magdalena (Date of defense: 2021-11-09)

La enfermedad del hígado graso no alcohólico es una patología sin tratamiento farmacológico específico que posee una alta prevalencia a nivel mundial, cuya etapa inicial se caracteriza por la esteatosis hepática simple. ...