Now showing items 35-46 of 46

    Safety and efficacy investigations for new prenatal neuroprotective therapies. Applications in a model of intrauterine growth restriction (IUGR). 

    Kühne, Britta Anna (Date of defense: 2022-10-21)

    [eng] Intrauterine growth restriction (IUGR) is defined as a significant reduction on fetal growth rate, resulting in a birth weight below the 10th percentile for the corresponding gestational age (Sharma et al., 2016). ...

    Síntesis de alcaloides decahidroquinolínicos de los grupos de la gefirotoxina, flegmarina y cilindricina 

    Piccichè, Miriam (Date of defense: 2021-12-10)

    Los alcaloides decahidroquinolínicos (DHQs) representan un pequeño grupo de productos naturales aislados mayoritariamente de fuentes animales, ya sean de origen terrestre o de origen marino, y en menor medida de fuentes ...

    Síntesis de compuestos bioactivos: Ligandos de los receptores imidazolínicos I(2) e inhibidores de la enzima PEPCK 

    Rodríguez Arévalo, Sergio (Date of defense: 2021-11-26)

    La síntesis de compuestos orgánicos heterocíclicos permite acceder a un amplio arsenal de compuestos con potencial actividad farmacológica. El presente manuscrito se enmarca en el campo de la química farmacéutica, desarrollando ...

    Síntesis formal enantioselectiva del macrólido calispongiolida 

    Urbina Teixidor, Aina (Date of defense: 2020-06-19)

    La calispongiolida es un macrólido aislado en el año 2013 a partir de un extracto metanólico de la esponja Callyspongia sp. recogida en la costa de Indonesia. Este producto natural posee una potente actividad citotóxica y ...

    Stress influence in neurodegeneration. Unravelling the mechanisms underlying stress response in brain ageing by 11ß-HSD1 inhibition 

    Puigoriol Illamola, Dolors (Date of defense: 2020-09-10)

    The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have ...

    Synthesis of 2-Vinyl sphingolipids as S1PL inhibitors 

    Calderón i Almendro, Raquel (Date of defense: 2017-03-14)

    Sphingolipids (SLs) are components of eukaryotic cell membranes that in the last 30 years have shown not only a structural role but also be involved in signaling processes and cellular responses. Therefore, the development ...

    Synthesis of nitrogenated compounds with potential interest for the treatment of Unmet Medical Needs 

    Bagán Polonio, Andrea (Date of defense: 2022-09-23)

    The synthesis of heterocyclic organic compounds allows access to a wide arsenal of compounds with potential pharmacological activity. This Thesis is part of the field of pharmaceutical chemistry, developing new therapeutic ...

    Targeting the I(2) Imidazoline Receptors: the neuroprotective role of selective ligands in Alzheimer’s Disease 

    Vasilopoulou, Foteini (Date of defense: 2021-09-21)

    The identification of imidazoline receptors (IR) as a novel class of receptors has posed manifold research questions regarding their pharmacological and potential therapeutic properties. Among them, I2-IR receptors are ...

    Total Synthesis of Phlegmarine Alkaloids 

    Bosch, Caroline (Date of defense: 2016-10-21)

    This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists ...

    Toward the Synthesis of Daphniphyllum Alkaloids using Radical Chemistry 

    Coussanes, Gilhem (Date of defense: 2016-12-16)

    The manuscript of this Doctoral Thesis has been divided into five main parts: a general introduction into the calyciphylline A-type alkaloids followed by three research chapters and conclude by a review about the radical ...

    Una estrategia unificada para la síntesis enantioselectiva de los alcaloides del grupo de las madangaminas 

    Are, Celeste (Date of defense: 2018-09-28)

    El presente trabajo se centra en los alcaloides del grupo de las madangaminas, un pequeño grupo de alcaloides diaminopentacíclicos, aislados de esponjas marinas pertenecientes al orden Haplosclerida y derivados biogenéticamente ...

    Validación de dianas farmacológicas para la prevención y el tratamiento de la hipertrigliceridemia y el hígado graso inducidos por el consumo de fructosa líquida y dieta rica en grasa saturada 

    Velázquez Chávez, Ana Magdalena (Date of defense: 2021-11-09)

    La enfermedad del hígado graso no alcohólico es una patología sin tratamiento farmacológico específico que posee una alta prevalencia a nivel mundial, cuya etapa inicial se caracteriza por la esteatosis hepática simple. ...