Now showing items 122-141 of 315

    Estudios galénicos de nuevas terapias analgésicas tópicas 

    Sanz Casañas, Roser (Date of defense: 2017-10-04)

    El dolor es una de las afecciones más referidas en la consulta clínica y en su tratamiento se utilizan distintos medicamentos según su intensidad, duración, etiología o enfermedad subyacente. La terapia analgésica comprende ...

    Estudios in vitro, ex vivo e in vivo de formulaciones de pranoprofeno para administración ocular 

    Cañadas Enrich, Cristina (Date of defense: 2018-11-28)

    El presente trabajo de investigación versa sobre la caracterización in vitro, ex vivo e in vivo de dos sistemas nanoestructurados de liberación sostenida (PF-F1NPs y PF- F2NPs) conteniendo pranoprofeno (PF) como principio ...

    Estudis d'Enginyeria Cristal·lina i Polimorfisme dels compostos nutracèutics Pterostilbé, Ubiquinol i Vitamina D3 

    Bofill Herrera, Lidia (Date of defense: 2021-09-13)

    La salut ha estat sempre una de les principals preocupacions de la societat, i més encara amb la situació de pandèmia actual produïda pel virus (SARS-CoV-2) s’és conscient de que portar un estil de vida amb bons hàbits ...

    Evolution of I34 modifications in tRNAs and their role in proteome composition 

    Rafels Ybern, Àlbert (Date of defense: 2018-07-17)

    Inosine is a guanosine analogue that when is found at the wobble position of the tRNAs (I34) expands its codon recognition capability. Inosine can wobble pair with cytosine, adenosine and uridine. Because inosine is not ...

    Exploring molecular mechanisms of key targets in metabolic and infectious diseases 

    Aledavood, Elnaz (Date of defense: 2021-10-01)

    This doctoral thesis is focused on disclosing molecular factors that regulate the functional mechanism of key targets in i) metabolic disorders, such as diabetes and obesity, and ii) tuberculosis (TB). These diseases have ...

    Exploring T-DNA gene mechanisms and optimizing centelloside production in Centella asiatica hairy root cultures 

    Alcalde Alvites, Miguel Angel (Date of defense: 2023-12-19)

    [eng] Plant biofactories constitute an eco-friendly alternative to chemical synthesis as they have a lower environmental impact and therefore contribute to a more sustainable future. Hairy root cultures, generated by ...

    Fatty acids and antioxidants in older adults with visual impairment: A contribution to Healthy Ageing 

    Caballero Arredondo, Mariana (Date of defense: 2023-01-24)

    [eng] This research aims to study the effect of supplementation with docosahexaenoic acid (DHA) and antioxidants in older adults diagnosed with age-related macular degeneration or cataracts to contribute to preventive ...

    Fatty Acids in Obese Pregnancies: Maternal and Child Outcomes 

    Garza Puentes, Andrea de la (Date of defense: 2017-09-28)

    Maternal obesity has implications on the health of future generations by early life programming. The mother is usually the main source of nutrients for the fetus and neonate, hence her nutritional status is crucial for ...

    Formación y caracterización de nanosistemas terapéuticos con alginato 

    Bonilla Valladares, Pablo (Date of defense: 2016-11-18)

    El alginato es un polímero aniónico ampliamente utilizado en aplicaciones farmacéuticas y biomédicas, debido a sus propiedades características como son la ausencia de toxicidad, biodegradabilidad, fácil disponibilidad, ...

    Formación y caracterización de sistemas terapéuticos a partir de emulsiones agua-en-agua 

    Figueroa Becerra, Esteban (Date of defense: 2023-03-02)

    [spa] Las emulsiones W/W son dispersiones de dos fases acuosas inmiscibles, que presentan la compartimentalización multifásica de las emulsiones convencionales sin requerir la presencia de solvente orgánico ni tensioactivo ...

    Funció del factor d'elongació eEF1A2 en plasticitat sinàptica 

    Gutiérrez Fernández, Sara (Date of defense: 2018-04-26)

    La plasticitat sinàptica és la capacitat que té el sistema nerviós de canviar la seva estructura i funcionament al llarg del desenvolupament. En processos d’aprenentatge, es formen noves espines dendrítiques que permetran ...

    Funció i potencial terapèutic de CPEB4 en l’aparició i progressió de lesions hepàtiques en context d’obesitat 

    Ramírez Pedraza, Marta (Date of defense: 2020-12-18)

    El carcinoma hepatocel·lular (HCC) és la segona causa de mort relacionada amb càncer i té avui en dia opcions terapèutiques molt limitades. Tot i que el HCC s’acostuma a estudiar en estats de malaltia hepàtica molt avançats, ...

    Functional analysis of a phloem cysteine protease in Arabidopsis thaliana 

    Pitsili, Eugenia (Date of defense: 2021-11-04)

    Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite diverse, from ...

    Galenic development of a new sunscreen product for skin cancer prevention 

    Amorós-Galicia, Lola (Date of defense: 2023-02-08)

    [eng] Sunscreen application is one of the best methods to prevent erythema, keratogenic cancer, melanoma and premature skin ageing. UV filters are the active substances preventing the harmful effects. Commercial UV filters ...

    Genetics of natural variation and environmental modulation of immune-related hybrid incompatibilities in Arabidopsis 

    Atanasov, Kostadin Evgeniev (Date of defense: 2019-05-14)

    Arabidopsis thaliana is a small ruderal weed with prominent north-hemisphere distribution. It has an autogamous style of reproduction, whereas about 3% of the natural population can exhibit outcrosses. Some of these ...

    Glycogen regulates cellular proliferation in the context of aging, tumorigenesis, and hepatic regeneration 

    Zapata Garin, Claire-Alix (Date of defense: 2018-06-01)

    Glycogen is a branched polysaccharide that serves as an intracellular store of glucose that can be mobilized to maintain homeostasis or to fuel cellular processes. Glycogen is synthesized by glycogen synthase, which is ...

    Gαq regulates mitochondrial motility and interacts with ALEX3, MIRO1 and TRAK proteins 

    Izquierdo Villalba, Ismael (Date of defense: 2020-01-17)

    G proteins transduce a myriad of signals from receptors at the plasma membrane. Recent reports point to a novel localization of G proteins at the mitochondria and other endomembranes where they regulate the physiology of ...

    Health-promoting phenolic compounds in extra virgin olive oil: an integrated study of their concentration and bioavailability 

    López Yerena, Anallely (Date of defense: 2021-09-28)

    The health promoting attributes associated with following a traditional Mediterranean diet have been reviewed extensively. The principal source of dietary fat in the Mediterranean diet is Extra virgin olive oil (EVOO) that ...

    Heterogeneity of carcinoma-associated fibroblasts and REV-ERB-induced phenotype molding in pancreatic ductal adenocarcinoma 

    Albert Colomer, Nerea (Date of defense: 2021-01-18)

    Tumor-stroma crosstalk is essential for PDAC formation. Therefore, the stroma, and specifically the carcinoma-associated fibroblasts (CAFs), are the target of therapeutic alternatives to treat highly desmoplastic tumors ...

    Human Primary Organoid-Derived Epithelial Monolayers as a Novel Strategy for the Study of Adherent Invasive Escherichia coli pathogenicity and the effects of Postbiotics on Intestinal Epithelial Function 

    Mayorgas, Aida (Date of defense: 2021-09-08)

    Inflammatory bowel disorders – such as Inflammatory Bowel Disease (IBD) – are rising worldwide. A well-known feature of IBD is dysbiosis of the gut microbiota, characterized by a significant reduction of beneficial strains ...