Domostegui Fernández, Ana (Date of defense: 2019-12-05)
The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that ...
Viayna Gaza, Antonio (Date of defense: 2019-07-19)
La presente tesis doctoral se divide, de forma general, en dos principales vertientes, una de carácter metodológica y otra de carácter aplicada. La primera de ellas se ha focalizado en la caracterización ...
Vázquez Lozano, Javier (Date of defense: 2019-09-13)
Three-dimensional ligand-based virtual screening methods have been used for many years in drug discovery, with a variable success depending on different factors, such as the complexity of the target ...
Atanasov, Kostadin Evgeniev (Date of defense: 2019-05-14)
Arabidopsis thaliana is a small ruderal weed with prominent north-hemisphere distribution. It has an autogamous style of reproduction, whereas about 3% of the natural population can exhibit outcrosses. ...
Balcells Nadal, Cristina (Date of defense: 2019-12-19)
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems ...
Quintana Agustí, Mireia (Date of defense: 2019-09-30)
This thesis addresses three different subjects closely related. First, a phenotypic screening measuring cytotoxicity in the gastric cancer cell line HGC-27 is reported. Next, a targeted-based assay ...
Vais, Ricardo Silva dos Santos (Date of defense: 2019-12-13)
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, ...
Toribio Isaías, Luis Daniel (Date of defense: 2019-12-18)
The aim of this project is to structurally characterize proteins involved in bacterial signal transduction systems by applying X-ray crystallography. Bacteria use signal transduction systems to react ...
Zamora Ramírez, William J. (Date of defense: 2019-02-22)
Lipophilicity is a key physicochemical descriptor used to understand the biological profile of (bio)organic compounds, xenobiotics and a broad variety of biochemical, pharmacological, and toxicological ...
Sostoa Pomés, Jana de (Date of defense: 2019-05-31)
Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor- associated stroma limits the ...