Martínez Campanario, María del Carmen (Date of defense: 2021-05-27)
Macrophages polarization from an inflammatory to a tolerogenic state occurs in both physiological and pathological, and this reprogramming is key in the development of several diseases as different as ...
Riera-Punet, Nina (Date of defense: 2019-03-01)
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive degeneration of the lower (LMN) and upper motor neurons (UMN) in the spinal cord and brain, ...
Casulleras i Oliver, Mireia (Date of defense: 2022-07-15)
[eng] This doctoral thesis is divided in two studies with the commune aim of elucidating the molecular mechanisms of albumin on leukocytes, in the context of advanced liver cirrhosis. The first study ...
Torrens Fontanals, Laura (Date of defense: 2022-03-07)
[eng] 1. HYPOTHESES. Primary liver cancer is the sixth most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide2,3. Around 90% of cases correspond to hepatocellular ...
Catalán García, Marc (Date of defense: 2017-03-20)
Sporadic inclusion body myositis (sIBM) is the most common myopathy in elderly. This disease causes muscle wasting with both distal and proximal affectation. Quadriceps and finger flexors are muscle ...
Rofes Terrón, Paula (Date of defense: 2022-03-31)
The overarching aim of the present thesis project is to implement new testing strategies and develop new tools that will contribute to improve the genetic diagnosis of hereditary cancer, with the ultimate ...
Solé Font, Laura (Date of defense: 2021-07-02)
Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that eradicate highly proliferative malignant cells. Whether sublethal chemotherapy affects tumour cell behaviour and ...
Profitós Pelejà, Núria (Date of defense: 2020-07-29)
ZEB1 and ZEB2 are two transcription factors best known for their role driving a dedifferentiation process, commonly referred as epithelial to mesenchymal transition (EMT). This process is carried out ...
Baroni, Matteo Libero (Date of defense: 2020-07-17)
[eng] Resistance to standard therapy and relapses are observed in several cases of both myeloid and lymphoid cell malignancies. Such phenomenon poses unquestionable limits to the utility of current ...
Cabot, Débora (Date of defense: 2020-09-28)
[eng] Analysis of KRAS phosphorylation and KRAS effector domain as targets for cancer therapy Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer (CRC). ...