Busquets i Viñas, Ma. Antonia (Date of defense: 1985-01-01)
Els liposomes o vesícules lipídiques van ésser descrites per primera vegada als anys seixanta per Bangham i Horne (1962), després de l'observació per microscopia electronica d'una suspensió de ...
dos Reis Mendes, Soraia Inês (Date of defense: 2022-10-28)
[eng] Several proteases and their antagonistic protein or peptide inhibitors sparked researchers’ interest due to their potential as therapeutic targets. The present thesis, which compiles results ...
Frager, Petra (Date of defense: 2022-10-28)
[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in ...
Abad i Lázaro, Aina (Date of defense: 2023-07-20)
[eng] The standard in vitro model of the small intestine in the field of drug development still consists in a monolayer of cancer-derived cells seeded on a hard substrate. Despite the huge advances ...
Garnica Caparrós, Josep (Date of defense: 2022-11-10)
[spa] Descripción de los eventos transcriptómicos y epigenéticos que tienen lugar en la diferenciación de TFH a TR1 mediada por el tratamiento con nanopartículas decoradas con complejos péptido-MHC, ...
Lewis, Michael (Date of defense: 2022-11-11)
[eng] Transcriptional regulation is a multifaceted and fundamental process, which underpins normal physiology, and its dysregulation is associated to numerous pathologies. Using two inherently different ...
Ramiro-Pareta, Marina (Date of defense: 2022-03-31)
The pleiotropic WT1 transcription factor (WT1) was first discovered in renal tumours. It contains four zinc-finger motifs at the C-terminus which are important for DNA binding to activate gene expression ...
Plana-Bonamaisó, Anna Maria (Date of defense: 2020-05-15)
The main aim of this work was to characterize the molecular mechanisms that underlie the physiopathology of LCA12 and RP10, that are inherited retinal dystrophies caused by alterations in guanine ...
Proaño Pérez, Elizabeth (Date of defense: 2022-11-30)
[eng] KIT (CD117) is a tyrosine kinase receptor expressed in hematopoietic progenitors, melanocytes, germ cells, mast cells, and interstitial cells of Cajal (ICC) of the digestive tract. KIT gain-of-function ...
Gordaliza Alaguero, Isabel (Date of defense: 2021-11-29)
Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, ...