Hardy-Werbin, Max (Date of defense: 2020-01-30)
El cáncer de pulmón de célula pequeña (CPCP) es el subtipo mas agresivo del cáncer de pulmón. Mas de la mitad de los pacientes se diagnostican con enfermedad diseminada, donde el tratamiento de elección ...
Llàcer Nicolás, Enric (Date of defense: 2016-01-20)
En el present treball de Tesi Doctoral s’ha desenvolupat una ruta sintètica per a l’obtenció de la fluvirucina B2 o Sch 38518. Realitzant petits canvis en cadascuna de les rutes convergents que la ...
Martínez Cartró, Míriam (Date of defense: 2021-10-25)
Advances in structural and molecular biology have increased the knowledge of relevant and undrugged targets and have favoured the rational development of novel drugs through structure- based ...
Benítez, Sandra (Date of defense: 2021-01-13)
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive ...
Noguera-Castells, Aleix (Date of defense: 2022-01-31)
Modern oncology conceives solid tumours as organs by themselves, meaning that not only should the behaviour of cancer cells to be considered and evaluated therapeutically, but also the so-called tumour ...
Ramírez Peinado, Silvia (Date of defense: 2012-09-25)
Las células tumorales presentan alteraciones metabólicas. Una de las diferencias con las células no transformadas es que los tumores usan más glucosa incluso en condiciones de normoxia, lo que se utiliza ...
Manzano Muñoz, Albert (Date of defense: 2022-12-15)
[eng] Personalized medicine has emerged to improve cancer treatment beyond classical approaches. The identification of genetic mutations by molecular analyses dominate personalized medicine initiatives ...
Fernández Plana, Julen (Date of defense: 2019-01-09)
El tractament de quimioteràpia associada a fàrmacs anti-EGFR representa un estàndard de tractament oncològic per a un subgrup de pacients amb Càncer colorectal metastàtic (CCRm). Malgrat això, no tots ...
Moreno Monasterio, Marta (Date of defense: 2015-02-18)
The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, ...
Gelabert Baldrich, Mariona (Date of defense: 2014-09-19)
En els últims anys les endomembranes cel•lulars, especialment les del compariment endocític (endosomes primerencs, EE; tardans LI / MVBs) estan adquirint rellevància com a plataformes de senyalització ...