Maceda Porto, Iago (Date of defense: 2021-04-28)
In this work we present a new whole genome sequencing dataset with samples gathered from the Spanish Eastern Pyrenees (SEP) with more than 40x coverage. We apply both classical and new methods to ...
Arcas Mantas, Aida (Date of defense: 2013-04-25)
The DNA Damage response is a crucial signaling network that preserves genome integrity. This network is an ensemble of distinct but often overlapping sub-networks, where participating components exert ...
Bellora Pereyra, Nicolás (Date of defense: 2010-02-26)
Regulation of gene transcription is a complex process involving many different proteins, some of which bind in a sequence-specific manner to DNA motifs in the gene promoter. The need to maintain specific ...
Hartasánchez Frenk, Diego Andrés (Date of defense: 2016-11-22)
Les regions duplicades del genoma, com ara les duplicacions de segments (SDs), són una característica comuna dels genomes eucariotes i han estat associades a canvis fenotípics. Donada la seva rellevància ...
López Escardó, David (Date of defense: 2018-01-15)
Opisthokonta is an eukaryotic supergroup that contains Metazoa, Fungi and their unicellular relatives. Therefore, this group provides an ideal framework to study distinct unicellular-multicellular ...
Pohl, Andy (Date of defense: 2014-10-03)
Genome-wide analysis of the nucleosome positioning and histone H1 isoform content of the T47D breast cancer cell line has found a number of observations, namely that with a gentle digestion of microccocal ...
Villanueva Cañas, José Luis (Date of defense: 2015-11-20)
Although the genome sequencing revolution is still in its infancy, we must acknowledge it as the major driver of biology since the beginning of the 21st century. The availability of a large collection ...
Cerutti, Andrea (Date of defense: 2013-07-19)
Immunoglobulin (Ig) diversification is essential for the generation of protective immune responses against intruding microbes. B cells require cognate interaction with T cells to generate protective ...
Noriega Esteban, Núria (Date of defense: 2009-02-27)
La adaptación de la levadura Saccharomyces cerevisiae a condiciones de alta osmolaridad está mediada por la vía de HOG ((high-osmolarity glycerol). La activación de esta vía induce una serie de respuestas ...
Serra Vidal, Gerard (Date of defense: 2018-12-05)
Àfrica és l'origen de totes les poblacions humanes actuals, i malgrat contenir els nivells més elevats de diversitat genètica, la seva història demogràfica ha estat relativament poc estudiada, amb moltes ...