Soria Rodríguez, Guadalupe (Date of defense: 2006-06-21)
La adicción es un trastorno crónico de la conducta caracterizado por la búsqueda y el consumo compulsivos de la droga, la pérdida de control para limitar dicho consumo, a aparición de un estado emocional ...
Han, Sojung (Date of defense: 2019-10-16)
Bonobos are an interesting species to study due to their unique evolutionary features such as a peaceful social nature and hypersexual behavior. The prolonged exaggerated sexual swelling in females ...
Serrano Candelas, Eva (Date of defense: 2012-12-20)
The protein phosphatase calcineurin (Cn), together with its substrates, the transcription factors NFATc, play an essential role in several physiological processes of vertebrates, such as the immune ...
Sampietro Bergua, Mª Lourdes (Date of defense: 2007-01-19)
In this thesis we have addressed three different although related topics. First, we studied the post-mortem mutation damage rate of contaminated DNA sequences in ancient human remains focusing on the ...
Dobón Berenguer, Begoña (Date of defense: 2018-11-23)
The evolution of the genome is driven, among other factors, by the composition of the genome, the functional output of the gene products, and by environmental pressures. Among the environmental factors, ...
Kuderna, Lukas (Date of defense: 2020-01-24)
Genomic analyses are at the center of contemporary biology. These studies heavily rely on reference genome assemblies, yet those are typically highly fragmented. Having accurate representations of complex ...
Brasó-Vives, Marina (Date of defense: 2019-01-18)
La duplicació és el principal mecanisme de formació de nou material genètic i d'innovació funcional. Entendre com les duplicacions sorgeixen, evolucionen, co-evolucionen i engendren noves funcions és ...
Antonelli, Maria Carla (Date of defense: 2021-03-24)
During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class ...
Martínez Marigorta, Urko (Date of defense: 2012-11-12)
The aetiology of common diseases is shaped by the effects of genetic and environmental factors. Big efforts have been devoted to unravel the genetic basis of disease with the hope that it will help to ...
Valles Ibáñez, Guillem de (Date of defense: 2016-11-16)
Human genomes have been found to harbor an unexpected number of ~100 loss-of-function (LoF) variants, with ~20 of them in an homozygous state, in most cases without a visible effect despite its potential ...