Mostrando ítems 1-20 de 20
Guerrero Barrado, Pedro Enrique (Fecha de defensa: 2020-07-29)
Pancreatic Ductal Adenocarcinoma (PDA), the most common pancreatic cancer, remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. Expression ...
Carrion-Salip, Dolors (Fecha de defensa: 2014-09-17)
Most current chemotherapeutic agents are of limited use due to their side effects and the resistance to treatment that tumour cells develop. In this thesis, we have contributed to the knowledge of these limitations through ...
Panosa Roqueta, Clara (Fecha de defensa: 2015-12-14)
The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that ...
Cufí González, Sílvia (Fecha de defensa: 2015-05-22)
Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics de les cèl•lules mare ...
Díaz Santa, Johana Alejandra (Fecha de defensa: 2022-12-16)
Acute myeloid leukemia (AML) is adults' most common acute leukemia. Prognostic factors influencing treatment response and patient survival are diverse, the most relevant being those associated with specific cytogenetic and ...
Farrés Coll, Ramon (Fecha de defensa: 2023-03-10)
Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...
Ferrer Soler, Laura (Fecha de defensa: 2007-03-30)
L'inhibidor de carboxipeptidasa de patata (PCI) és un antagonista de l'EGF. Un dels problemes del PCI, però, és la baixa afinitat per l'EGFR en comparació amb el lligand natural. En aquest treball s'han dissenyat nous ...
Santos Carvajal, Nazly (Fecha de defensa: 2022-11-25)
Study of the impact of UGT2B17 and PD-1 on allogeneic transplantation of hematopoietic progenitors (allo-TPH) from HLA-identical related donor. everal genetic factors can favor the development of graft-versus-host disease ...
Pigem Rodeja, Anna (Fecha de defensa: 2023-03-03)
INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...
Sarrats Carbó, Ariadna (Fecha de defensa: 2011-02-10)
Els pacients amb càncer presenten una taxa de supervivència superior si es diagnostiquen a estadis inicials, per la qual cosa és indispensable disposar de marcadors tumorals adequats. Glicoformes de proteïnes específiques ...
Blanco Aparicio, Carmen (Fecha de defensa: 1998-07-17)
In this work we report that potato carboxypeptidase inhibitor suppresses the growth of several human and mouse pancreatic adenocarcinoma cell lines. The inhibitor also reduces the growth of solid tumors obtained by ...
Miró Domènech, Laura (Fecha de defensa: 2023-01-13)
Pancreatic ductal adenocarcinoma (PDA) presents a dismal prognosis mainly due to its delayed diagnosis, its aggressiveness, and resistance to existing therapies. Aberrant glycosylation and, in particular, the overexpression ...
Ferri Iglesias, María José (Fecha de defensa: 2012-09-27)
Serum levels of several molecules associated to pancreatic adenocarcinoma (PDAC) pathophysiology are evaluated in this work, in order to determine their diagnostic value, distinguishing between PDAC patients and healthy ...
Duran Sidera, Adrià (Fecha de defensa: 2023-11-14)
Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis of the disease at ...
Chico Julià, Berta (Fecha de defensa: 2009-02-19)
La DM 2 és una malaltia multifactorial i multigènica. Aquest fet condueix a l'estudi de molts gens i proteïnes susceptibles d'estar implicades amb la DM 2. Algunes d'aquestes proteïnes i gens estan associats a un estat ...
Oliveras Ferrarós, Cristina (Fecha de defensa: 2013-06-21)
The aim of this doctoral thesis was to unravel mechanisms underlying primary resistance to trastuzumab regarding a putative new breast cancer subtype with mixed basal & ErbB2+ molecular features. Using the JIMT-1 breast ...
Balmaña Esteban, Meritxell (Fecha de defensa: 2016-07-07)
Cancer is one of the leading causes of death worldwide. Pancreatic ductal adenocarcinoma (PDAC) is characterized by high intrinsic aggressiveness and late diagnosis, causing poor prognosis and resulting in the lowest ...
Pérez Garay, Marta (Fecha de defensa: 2011-02-07)
Este trabajo demuestra que los genes que codifican para los enzimas beta-galactosido alfa-2,3-sialiltransferasa 3 (ST3Gal III), y en menor medida beta-galactosido alfa-2,3-sialiltransferasa 4 (ST3Gal IV), están directamente ...
Ruiz Martínez, Santiago (Fecha de defensa: 2016-07-08)
The main aim of the present study is to characterize the biological and biophysical properties of Apoptin, a viral protein that selectively induces apoptosis of a wide range of tumor cells. Apoptin has been produced and ...
Bravo Bonilla, Marlon Rolando (Fecha de defensa: 2022-06-16)
Cancer is the leading cause of death due to non-communicable diseases worldwide. Despite the advances in the development of new antitumor drugs, there are still problems such as the resistance that tumor cells acquire ...