Magallón Lorenz, Miriam (Date of defense: 2023-07-07)
[eng] Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft-tissues sarcomas of the peripheral nervous system (PNS) with poor prognosis and lack of therapeutic options. Complete resection with ...
Bujosa Rodriguez, Paula (Date of defense: 2023-09-27)
[eng] Linker histones are essential proteins involved in higher-order chromatin structures and architectural functions. However, their roles extend beyond structure, encompassing various chromatin ...
Salinas Pena, Mónica (Date of defense: 2023-09-20)
[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous ...
Sánchez Baizán, Núria (Date of defense: 2023-10-27)
[eng] Epigenetic mechanisms play a vital role in gene expression regulation and phenotype determination. This thesis aimed to comprehensively investigate the transcriptome, the methylome and the influence ...
Mendoza Blanco, Mónica (Date of defense: 2023-11-24)
[eng] Neurons are highly polarized cells that require protein synthesis in distal dendrites to fulfil local protein requirements on short timescales. The regulation of this process relies in two major ...
Giroud-Gernetant Deus, Judith (Date of defense: 2023-11-20)
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that ...
Muñoz Pujol, Gerard (Date of defense: 2023-11-23)
[cat] Les malalties metabòliques hereditàries (MMH) són un grup de patologies amb una gran heterogeneïtat clínica, bioquímica i genètica. Actualment se n’han descrit més de 1 800. En l’última dècada ...
Molina Jordán, Marc (Date of defense: 2023-12-04)
[eng] The application of mechanical force to the nucleus has been recently shown to regulate important functions, including nucleocytoplasmic transport (NCT), chromatin organization, and gene expression. ...
Qualai, Jamal (Date of defense: 2023-12-04)
[eng] Common sexually transmitted infections like gonorrhea, Chlamydia, syphilis, and trichomoniasis are the leading cause of morbidity in developing countries. Adolescents and young women have the ...
Xiol Viñas, Clara (Date of defense: 2023-12-22)
[eng] Rett syndrome (RTT) is a severe neurodevelopmental disorder characterized by a regression in acquired skills, such as purposeful hand use and language, after an apparently normal early development. ...