Mostrando ítems 1-20 de 1298
Alonso, Florencia Evelin (Fecha de defensa: 2024-06-04)
Currently, there are no antiviral strategies to rapidly respond to novel emerging viruses or to mosquito borne viruses. On this thesis we have developed an innovative artificial circular RNA (circRNA) antiviral platform ...
Bota, Patricia Mirela (Fecha de defensa: 2024-05-21)
Protein-protein interactions (PPIs) are fundamental in driving biological processes and maintaining life’s diverse functions. They play a key role in cellular regulation, facilitating our understanding of both basic ...
Turuban, Maxime (Fecha de defensa: 2024-05-15)
Radiofrequency electromagnetic fields (RF-EMF) exposure, ubiquitous in our environment due to the rise in mobile phones and wireless technology, has grown significantly in the last 30 years. This exposure is generally ...
Martín de Dios, Laura (Fecha de defensa: 2024-05-06)
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada en el interior ...
Bae, Hansol (Fecha de defensa: 2024-04-26)
Epigenetic modification serves as a crucial mechanism in regulating gene expression and facilitating cellular adaptation to environmental stress. This study aimed to identify histone residues and their associated ...
Aguilar Fernández, Sergio (Fecha de defensa: 2024-04-24)
The intrinsic complexity and dynamic nature of B-lymphocytes make them ideal for in-depth analysis using single-cell technologies. Secondary lymphoid organs (SLOs) are central in B-lymphocyte activation and differentiation, ...
Elek, Anamaria (Fecha de defensa: 2024-04-19)
Single-cell genomics methods have revolutionized the study of gene expression and regulation at the cell type level. Generating single-cell atlases for species at key phylogenetic positions of the animal tree of life (e.g.. ...
Khomenko, Sasha (Fecha de defensa: 2024-04-19)
The rapid increase in urbanization underscores the need for healthy urban environments. Presently, European cities experience high levels of air pollution, noise, lack of green spaces, and increased local temperatures, all ...
San José Plana, Adrià (Fecha de defensa: 2024-04-16)
The primary goal of this PhD is to deepen our understanding and improve the modeling capacity of zoonotic spillover, the multilevel process by which pathogens manage to overcome a series of natural barriers and infect other ...
Vidal, María Sol (Fecha de defensa: 2024-04-15)
Organisms need to integrate its previous experience with its current internal state in order to deliver a suitable response to dynamic changes in their environment. This thesis is devoted to analyze, using a mathematical ...
Suárez Ara, Patricia (Fecha de defensa: 2024-04-12)
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel the evolutionary ...
Dávalos Yerovi, Natalia Vanesa (Fecha de defensa: 2024-04-12)
Esta tesis aborda la malnutrición y la sarcopenia en pacientes con enfermedades crónicas, centrándose en la enfermedad pulmonar obstructiva crónica (EPOC) y la enfermedad renal crónica. Utilizando los criterios de la Global ...
Morales Pastor, Adrián (Fecha de defensa: 2024-04-11)
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation in pharmacotherapy. ...
Shekari, Mahnaz (Fecha de defensa: 2024-04-03)
This thesis explores technical factors influencing brain PET quantification, developing brain PET harmonization framework, assessing Centiloid robustness as a clinical biomarker, and evaluating the associations between ...
Delgado Tejedor, Anna (Fecha de defensa: 2024-03-21)
RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple biological processes, including splicing regulation, gene expression regulation and antibiotic resistance. Unfortunately, ...
Sondermann, Nathalie Allegra Faye (Fecha de defensa: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal translocations and ...
Londoño Cañola, Catalina (Fecha de defensa: 2024-03-18)
Esta tesis tiene como objetivos evaluar el entorno alimentario alrededor de las escuelas de Barcelona en términos de proximidad y disponibilidad de establecimientos alimentarios y su relación con el nivel socioeconómico ...
Fernández Ibarrondo, Lierni (Fecha de defensa: 2024-04-05)
Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones driver que afectan a la vía JAK/STAT. ...
Ivancic, Dimitrie (Fecha de defensa: 2024-04-03)
Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome editors has enabled ...
Özer, Ege Ekin (Fecha de defensa: 2024-03-21)
In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. In two experimental ...