Browsing by Title

Function of the histone demethylase PHF8 in neural progenitor cells and glial differentiation

Iacobucci, Simona (Date of defense: 2021-03-18)

Taking into consideration the current knowledge about the subjects treated, several goals were proposed for this PhD thesis in order to further understand PHF8 function in both astrocytes and neural stem cells biology. To ...

Functional adequacy: The effect of Englsih Medium Instruction, English Proficiency and previous language learning experiences

Herraiz Martínez, Ana (Date of defense: 2018-12-17)

This thesis analyses undergraduate learners' pragmatic development. The participants of the study were enrolled in English-medium instruction atlhree different Spanish universities. Pragmatic development is operationalised ...

Functional analyses of candidate genes for osteoporosis : RUNX2 and LRP5 interplay during differentiation of the hFOB human osteoblast cell line

Gholami, Behjat (Date of defense: 2017-09-18)

Osteoporosis is a general skeletal disorder. It is characterized by a low bone mass and a microarchitectural deterioration of bone tissue, which increase bone fragility and susceptibility to fracture. LRP5 is a widely ...

Functional analyses of tissue and organ specificity at the core of the arabidopsis circadian clock

Takahashi, Nozomu (Date of defense: 2017-09-26)

El reloj circadiano es un mecanismo celular responsable de la generación de ritmos biológicos con un periodo de 24 horas. La importancia de la función del reloj circadiano es evidente en casi todos los organismos estudiados ...

Functional analysis of a phloem cysteine protease in Arabidopsis thaliana

Pitsili, Eugenia (Date of defense: 2021-11-04)

Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite diverse, from ...

Functional analysis of candidate genes for meat quality traits and muscle transcriptomics in pigs

Criado Mesas, Lourdes (Date of defense: 2020-06-08)

Avui dia el consum mundial de carn està creixent, sent la carn de porc una de les més consumides. La millora de la qualitat de la carn està subjecta als requisits del consumidor per productes carnis més saludables i ...

Functional analysis of Drosophila melanogaster linker histone dH1

Vujatovic, Olivera (Date of defense: 2012-07-27)

We did functional characterisation of Drosophila melanogaster linker histone, dH1. In the mutant state for this protein, we observed structural changes in polytene chromosomes chromocenter and nucleoli of mutant larvae. ...

Functional analysis of EXD2 in mitochondrial homeostasis

Faria da Silva, Joana Raquel (Date of defense: 2017-03-24)

One of the most fundamental events in the history of life is the origin of mitochondria. It was firstly proposed by Ivan Wallin, and later popularized by Lynn Margulis, as part of the endosymbiotic theory, that mitochondria ...

Functional analysis of JmjC+N histone demethylases in Drosophila melanogaster

Lloret Llinares, Marta (Date of defense: 2011-05-17)

La metilació de les lisines de les histones està implicada en les funcions associades a la cromatina, com l’expressió gènica o la formació d’heterocromatina. És una modificació covalent afegida per metiltransferases ...

Functional analysis of Mobile toolkits in high-resolution Middle Paleolithic contexts: Abric Romaní (Barcelona, Spain) and Nahal Mahanayeem Outlet (NMO, Israel)

Martin-Viveros Diaz-Meco, Juan Ignacio (Date of defense: 2023-11-17)

Aquesta tesi doctoral es centra en una anàlisi funcional exhaustiva d'eines lítiques mòbils en dos jaciments del Paleolític Mitjà: Abric Romaní a Barcelona, Espanya, i Nahal Mahanayeem Outlet (NMO) a Israel. L'estudi ...

Functional analysis of position effects of inversion 2j in Drosophila buzzatii: gene CG13617 silencing and its adpative significance

Puig Font, Marta (Date of defense: 2010-12-23)

És sabut de fa molt temps que les inversions cromosòmiques son mantenides per selecció natural a les poblacions de Drosophila. No obstant, els mecanismes moleculars que generen aquest valor adaptatiu encara no es coneixen. ...

Functional analysis of the extraproteasomal ubiquitin receptor Dsk2/UBQLN in Drosophila and human cells

Di Mauro, Gianmarco (Date of defense: 2019-02-28)

Dsk2/UBQLN is a conserved extraproteasomal ubiquitin receptor that has been widely described as a protein involved in the ubiquitin proteasome pathway. In Drosophila, this protein has been recently reported in a non-proteolitic ...

Functional Analysis of the Lithic Assemblages from the Middle and Upper Paleolithic sites of Khorramabad Valley (Western Iran), with special reference to Kaldar Cave

Tumung, Laxmi (Date of defense: 2019-04-12)

Aquesta tesi se centra en l'estudi funcional de conjunts de Paleolític mitjà i superior de la Vall de Khorramabad (Iran occidental), amb especial atenció a la cova de Kaldar. S'emmarca en un projecte de recerca multidisciplinària ...

Functional analysis of variant proteins in Plasmodium vivax: Implications in pathology

Bernabeu Aznar, Maria (Date of defense: 2013-06-14)

P. vivax is the most widespread malaria, it accounts for 25-40% of the global disease burden and it is estimated that causes from 132 to 391 million clinical cases each year. It is amply accepted that P. vivax do not ...

Functional and evolutionary implications of single nucleotide substitutions in human microRNAs across primates

López Valenzuela, María (Date of defense: 2015-01-15)

MicroRNAs (miRNAs) are major contributors to phenotypic diversity and have a demonstrated role in evolution. We performed an analysis on how miRNA nucleotide substitutions may have contributed to human divergence from their ...

Functional and molecular characterization of maize open stomata 1 protein kinase

Vilela, Belmiro (Date of defense: 2012-12-18)

Plant growth and productivity are compromised by environmental stresses such as pathogens, extreme temperatures, drought and high salinity. Being sessile organisms, plants had to develop different physiologic and biochemical ...

Functional and Phylogenetic Diversity of Amphibians in the Brazilian Atlantic Forest: Implications for a Systematic Conservation Planning

Siqueira Campos, Felipe (Date of defense: 2018-06-18)

Biodiversity patterns are results of ecological and evolutionary processes. Understanding the forces shaping biodiversity patterns help to predict the responses of ecosystems to environmental change. Considering the role ...

Functional and structural analyses of the terminal organelle of Mycoplasma genitalium

González González, Luis (Date of defense: 2015-12-04)

Mycoplamsa genitalium es un patógeno humano causante de uretritis no gonocócica y no causada por clamidias en hombres y de enfermedad pélvica inflamatoria y cervicitis. Los micoplasmas, además de ser muy interesantes para ...

Functional and structural studies of AKR1B15 and AKR1B16: Two novel additions to human and mouse aldo-keto reductase superfamily

Giménez Dejoz, Joan (Date of defense: 2016-07-22)

La superfamília de les aldo-ceto reductases (AKR) comprèn un gran nombre de proteïnes monomèriques de localització citosòlica d’un un pes molecular d'aproximadament 36 kDa. Les AKRs tenen un plegament proteic comú evolutivament ...

Functional characterization in vivo of essential Saccharomyces cerevisiae's hydrophilin for desiccation tolerance

López Martínez, Gema Isabel (Date of defense: 2015-07-22)

La sobre expressió de les hidrofilines STF2 i SIP18 en soques de laboratori, tenen un efecte positiu en la tolerància a la deshidratació i rehidratació. A més, la sobre expressió de SIP18 en quatre soques comercials de ...