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Now showing items 20918-20937 of 41729
Identification and functional analysis of molecular mechanisms involved in the latency of ER positive breast cancer
Breast cancer is the most frequently diagnosed cancer and remains the second leading cause of death among women in Europe and United States. In this malignancy, metastasis remains to be an incurable condition, and therefore ...
Identification and functional analysis of new factors that mediate tramtrack's function during Drosophila tracheal system development / Identificación y análisis funcional de nuevos factores que median la función de tramtrack durante el desarrollo del sistema traqueal de Drosophila
A stereotyped tubular epithelial network forms many of our bodies’ organs and, defects in the formation of these tubules often leads to organ failure. My Thesis project aims to further understand the mechanisms underling ...
Identification and functional characterization of genetic loci involved in osteoporosis and atypical femoral fracture
Osteoporosis is a complex disease, determined by genetic and environmental factors, characterized by a low bone mass and microarchitectural deterioration of bone tissue, with a consequent decrease of bone strength and ...
Identification and functional characterization of P1N-PISPO, a new gene product present in sweet potato potyviruses
Sweet potato feathery mottle virus (SPFMV) (Potyvirus genus, Potyviridae family) causes important yield losses in sweet potato crops, in particular in co-infections with the unrelated crinivirus Sweet potato chlorotic stunt ...
Identification and partial characterization of acid phosphatases from Haemophilus parasuis
Haemophilus parasuis es una bacteria Gram negativa común en el tracto respiratorio superior de cerdos sanos y es el agente etiológico de la enfermedad de Glässer, que se caracteriza por poliserositis fibrinosa y poliartritis. ...
Identification and phylogeny of clinical and environmental isolates of Alternaria, Cladosporium and other genera of dematiaceous hyphomycetes
La present tesi s’ha centrat en l’estudi de la diversitat d’espècies i la taxonomia dels gèneres Alternaria i Cladosporium, així com d’altres gèneres d’hifomicets dematiàcis morfològicament similars. S’han estudiat un total ...
Identification and validation of phenotypes in a cohort of patients with obstructive sleep apnea
Introducció. L'apnea obstructiva del son (AOS) és una malaltia heterogènia, complexa, que s'associa a múltiples comorbiditats. L'objectiu d'aquest estudi és identificar fenotips d'AOS mitjançant una anàlisi de clúster, fer ...
Identification by virtual screening of protein tyrosine phosphatase 1B and matrix metalloproteinase 13 inhibitors for the treatment of obesity and obesity-associated disorders
L'obesitat és un dels principals problemes de salut pública del segle XXI. La gran expansió econòmica de les últimes dècades en els països desenvolupats ha contribuit a l’increment del consum d’aliments poc saludables i a ...
Identification de facteurs d'intégration quantitatifs et qualitatifs des néologismes à la langue spécialisée médicale: une analyse sur corpus diachronique entre 2007 et 2015
La evolución del lenguaje médico refleja los avances médicos y se caracteriza por la creación neológica destinada a nombrar nuevos descubrimientos e innovaciones. Por lo tanto, la creación neológica, la variación terminológica ...
Identification of a new deadenylation negative feedback loop that regulates meiotic progression
Els oòcits de vertebrats es troben aturats a la profase I de la primera meiosi (PI). Durant el procés anomenat oogènesi, els oòctits sintetitzen i emmagatzemen grans quantitats d'ARN missatgers(ARNm)que els seran necessaris ...
Identification of a risk transcriptome and proteome in Parkinson’s disease, Dementia with Lewy bodies and rapidly progressive Dementia with Lewy bodies
Parkinson's disease (PD) is a neurodegenerative disorder characterized by movement impairment, or parkinsonism, for which there is still no cure. The manifest clinical signs result from neuronal loss of more ...
Identification of altered regulatory interactions in disease
Gene regulation is a complex biological process that requires the coordinated interaction of different molecules. The integrity of the underlying mechanisms ensures the correct expression of genes that maintain cell ...
Identification of clinically relevant genetic variation in immune-mediated inflammatory diseases using genome-wide approaches
Rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic lupus erythematosus, Crohn’s disease and ulcerative colitis are six of the most prevalent immune-mediated inflammatory diseases (IMIDs) and are associated with ...
Identification of deubiquitinating enzyme genes relevant for the regulation of retina-specific genes
Protein post-translational modifications are regulatory mechanisms that cells use in response to intra- and extracellular signals. These signals modulate a panoply of conjugating enzymes that modify proteins post-translationally ...
Identification of differential biological mechanisms between pregnancy and postpartum in Rheumatoid Arthritis
L’embaràs a l’Artritis Reumatoide (AR) proporciona un model únic per l’estudi dels mecanismes biològics de la malaltia. Durant l’embaràs, generalment, es produeix una interrupció transitòria de l’activitat de l’AR que es ...
Identification of environmental variables in Drosophila melanogaster natural populations
Entender cómo las especies se adaptan al ambiente es aún una pregunta sin resolver en el campo de la Biología Evolutiva. Mientras el foco principal siempre ha estado en la base genética, los factores ambientales responsables ...
Identification of genetic determinants of breast cancer metastasis to the bone
El objetivo de esta tesis era identificar determinantes genéticos de cáncer de mama con metástasis óseas. Para ello se utilizó un enfoque integral que se sustenta en células humanas de cáncer de mama, modelos experimentales ...
Identification of genetic modifiers of penetrance in human inherited disease
Understanding the molecular basis of human inherited disease is a challenging task due to the complexity of mapping the genotype to the phenotype. The study of diseases running in families has shown that the inheritance ...
Identification of Genetic Susceptibility Factors for Fibromyalgia / Identificació de factors de susceptibilitat genètica per a fibromiàlgia
Fibromyalgia (FM) is a highly disabling syndrome defined by a low pain threshold and a permanent state of pain. Widespread pain is accompanied by a constellation of symptoms such as fatigue, sleep disturbances and cognitive ...
Identification of HIV-1 reactivating quinoline compounds as bromodomain inhibitors
Tras la infección por VIH-1, el establecimiento de un depósito de células T en reposo infectadas latentemente con VIH impide la erradicación del virus en pacientes. Para lograr la erradicación, la terapia retroviral existente ...
