Now showing items 28636-28655 of 41446

    Molecular characterization of the Ppz1 phosphatase and its regulatory subunit Hal3 

    Molero Merinero, Cristina (Date of defense: 2017-07-21)

    La proteína Ser / Thr fosfatasa Ppz1 de S. cerevisiae es un componente importante en el mantenimiento de la homeostasis de cationes monovalentes (K+ y Na+) y, como tal, incide en múltiples procesos celulares, tales como ...

    Molecular charaterization of Primary Ciliary Dyskinesia| 

    Baz Redón, Noelia (Date of defense: 2022-09-01)

    Introduction: Motile cilia are highly complex hair-like organelles protruding from the apical surface of epithelia cells of various human organ systems. They contain a 9+2 tubulin-based axoneme core structure and an ...

    Molecular classification and biomarkers in hepatobiliary cancer 

    Montal Roura, Robert (Date of defense: 2020-10-07)

    [spa] El cáncer hepatobiliar (incluye principalmente el carcinoma hepatocelular [HCC] y el cáncer del tracto biliar [BTC]) representa la tercera causa de muerte relacionada con cáncer en todo el mundo [1]. Menos de la mitad ...

    Molecular computing methods for natural languge syntax 

    Bel Enguix, Gemma (Date of defense: 2001-03-07)

    Molecular containers based on aryl-extended calix[4]Pyrroles 

    Escobar González, Luis (Date of defense: 2019-10-31)

    Aquesta Tesi s'ocupa del disseny i síntesi de receptors còncaus que posseeixen cavitats hidrofíliques: receptors covalents, caixes metàl·liques i càpsules no covalents. Per a la seva construcció, triem la bastida de ...

    Molecular containers based on calix[4]pyrrole scaffolds 

    Galán Coca, Albano (Date of defense: 2016-01-29)

    Aquesta tesi compren la síntesi i l'estudi de diferents contenidors moleculars basats en una estructura macrocíclica de calix[4]pirrol. Els contenidors moleculars poseeixen cavitats polars funcionalitzades ideals per al ...

    Molecular details of prostaglandin synthesis catalyzed by cyclooxygenase-2 and its inhibition by aspirin 

    Cebrián Prats, Anna (Date of defense: 2020-05-13)

    La ciclooxigenasa-2 (COX-2) és un enzim hemoproteic, bifuncional, homodiméric associat a la membrana, el qual catalitza l’oxigenació de diversos PUFAs. La COX-2 és un dels dos principals enzims humans responsables dels ...

    Molecular determinants of human oocyte quality in assisted reproduction 

    Cornet Bartolomé, David (Date of defense: 2019-07-09)

    Infertility, defined by the World Health Organization (WHO) as the inability to conceive after a year of unprotected sex, is a disease that affects 1 in 9 couples of reproductive age worldwide. Most of these couples will ...

    Molecular determinants of the Kv1.3/KCNE4 interaction 

    Sastre Martinez, Daniel (Date of defense: 2022-04-08)

    Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...

    Molecular determinants of TRPV4 channel regulation 

    Garcia-Elias Heras, Anna (Date of defense: 2011-06-30)

    TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. Due to this ...

    Molecular dynamics simulations of seven-transmembrane receptors 

    Cordomí Montoya, Arnau (Date of defense: 2008-03-11)

    Seven transmembrane (7-TM) G protein coupled receptors (GPCR) constitute the largest family of integral membrane proteins in eukaryotes with more than 1000 members and encoding more than 2% of the human genome. These ...

    A molecular dynamics study of nanocontact plasticity and dislocation avalanches in FCC and BCC crystals 

    Varillas, Javier (Date of defense: 2019-06-17)

    This study aims to investigate the underlying mechanisms which govern the development of dense defect networks in nanoscale crystal plasticity, either under contact and uniaxial loading conditions, with emphasis on the ...

    Molecular epidemiological studies of Porcine circovirus 3, a novel virus identified in domestic pig and wild boar 

    Klaumann, Francini (Date of defense: 2018-11-09)

    El Circovirus porcino 3 (PCV-3) es un virus descubierto recientemente en cerdos domésticos y jabalíes. El virus fue hallado por primera vez en 2016 mediante estudios metagenómicos, en animales afectados por fallo reproductivo, ...

    Molecular epidemiology and mechanisms of cephalosporin resistance in escherichia coli of different origins; broilers, flies and white storks 

    Solà Ginés, Marc (Date of defense: 2018-03-13)

    Las bacterias resistentes a antibióticos, y en concreto a betalactamasas de espectro extendido (BLEEs), se han convertido en un problema grave. Su prevalencia ha incrementado rápidamente a nivel mundial debido a una ...

    Molecular epidemiology study on genetically regulated gene expression in the colonic mucosa and its role in disease susceptibility 

    Díez Obrero, Virginia (Date of defense: 2021-11-19)

    [spa] La expresión genética es un proceso celular clave, que además está relacionado con la susceptibilidad genética a enfermedades y rasgos complejos. La mayoría de genes se someten a splicing alternativo (AS). Las variantes ...

    Molecular Evolution of Unicellular Eukaryote Metallothioneins: Tandem Repetition of Coordinating Domains 

    Espart Herrero, Anna (Date of defense: 2015-09-16)

    Metallothioneins (MTs) are a superfamily of ubiquitous and small cysteine rich metalloproteins present in all eukaryotes and some prokaryotes organisms, that exhibit preferences to coordinate divalent or monovalent heavy ...

    Molecular genetics of autosomal dominant ataxias: identification and characterisation of two novel spinocerebellar ataxia subtypes 

    Corral Juan, Marc (Date of defense: 2021-02-05)

    Les atàxies espinocerebel·loses (SCAs) consisteixen en un grup heterogeni de trastorns del moviment hereditaris caracteritzats clínicament per atàxia progressiva associada de forma variable amb altres signes neurològics ...

    Molecular genetics of cork formation 

    Soler del Monte, Marçal (Date of defense: 2008-06-09)

    La peridermis és una estructura complexa que protegeix els òrgans vegetals madurs (secundaris) i les zones que han sofert ferides de la pèrdua d'aigua i dels patògens. Aquesta funció barrera és deguda al fel·lema o súber, ...

    Molecular identification and feeding ecology of arthropod generalist predators present in Mediterranean lettuce crops 

    Gómez Polo, Priscila (Date of defense: 2014-09-26)

    The aphid Nasonovia ribisnigri (Hemiptera: Aphididae) and the thrips Frankliniella occidentalis (Thysanoptera: Thripidae) are two of the main pests in Mediterranean lettuce crops. The general goal of this Doctoral Thesis ...

    Molecular insights into mammalian sperm physiology: a comparative study of glutathione S-transferases in male reproduction 

    Llavanera Bruguera, Marc (Date of defense: 2023-05-12)

    Male infertility is a global health problem affecting one in four infertile couples. This also has a negative repercussion on the animal breeding industry, where infertility has a detrimental impact on their balance sheets. ...