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Now showing items 32646-32665 of 41723
Poly-N-Heterocyclic Carbene Ligands with Polyaromatic Linkers. Self-Assembly and Host-Guest Chemistry
In summary, a series of polytopic ligands based on NHC and MIC ligands have been synthesized in this Doctoral Thesis by means of different synthetic routes that gave rise to systems with very sophisticated architectures. ...
Poly-victimization and its association with protective and vulnerability variables in adolescence: The mediating role of self-esteem
Interpersonal victimization is widely acknowledged to be a significant stressor and psychologically damaging factor for both children and adolescents. Despite the large number of studies that report a clear association ...
Polyamine metabolism during the defense response to Pseudomonas syringae in Arabidopsis thaliana
The topic of this thesis is to investigate the polyamine metabolism during defense response in Arabidopsis thaliana. I mainly focused on the alteration of polyamine metabolism in different layers of plant immunity triggered ...
Polyamine signaling pathway during environmental stress: Metabolomic approaches to elucidate spermine down-stream targets
Environmental stress is increasingly wearing down crop productivity. Nowadays, one of the main aims of plant research is to elucidate tolerance mechanisms to diverse stresses, in order to provide solutions by generating ...
Polybenzoxazine materials from renewable diphenolic acid
La síntesis de polímeros a partir de fuentes renovables como la biomasa es una forma viable de resolver los problemas relacionados con la contaminación del medio ambiente y la escasez de recursos derivados del petróleo ...
Polycarbodiimide synthesis optimization and its application as polymer stabilizer against degradation processes
Les carbodiimides s’utilitzen com a productes estabilitzants de polímers envers els processos de degradació mitjançant la seva reacció amb els nous compostos generats, reconstruint d’aquesta manera la estructura del polímer ...
Polycomb and KDM6A Roles in the Epigenetic Dynamics of Ewing Sarcoma Tumorigenesis
Ewing sarcoma (ES) is a highly aggressive tumour of the bone and soft tissue that typically affects children, adolescents, and young adults. The fusion protein EWSR1‐FLI1 is the main genetic alteration found that acts as ...
The Polycomb group protein Cbx6 is an essential regulator of embryonic stem cell identity
Polycomb group (PcG) proteins are transcriptional repressors that control cell identity and development. In mammals, at least five different Cbx prorteins are believed to associate with the core Polycomb repressive complex ...
Polycomb group proteins Bmi1 and Ring1B are involved in cell plasticity and tumorigenesis of the pancreas
L'adenocarcinoma ductal pancreàtic (PDAC) és un dels càncers més letals. Per tal de millorar el diagnòstic precoç, s'estan investigant les etapes inicials de la formació del càncer, com és el cas de les lesions preneoplàstiques, ...
Polycomb Repressive Complex 1 functions in differentiation and myelodysplastic syndromes
Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) components. On the one ...
Polycomb repressive complex 2 deregulation in tissue homeostasis and cancer
Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic lethality and disease, ...
Polycyclic group optimization in 11β-HSD1 inhibitors and their pharmacological evaluation
The present PhD Thesis evolves around the design, synthesis and pharmacological evaluation of novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. Given that the enzyme active site includes a hydrophobic ...
Polyene sphingolipids with latent fluorescence: new tools to study the biophysical properties of cellular membranes
One of the ultimate goals in biomedicine is to understand the relationship between structure, function, and dynamics of biomolecules in living cells. The biophysical tools designed to gain more insight into metabolism, ...
Polyesters containing cyclic carbohydrate-based units obtained by ring opening polymerization
In recent years, as a result of climate change, the interest in sustainable materials has increased dramatically. The replacement of compounds of petrochemical origin by bio-based has spread to all areas of chemistry. ...
Polyethylene glycol conditioning: An effective strategy to protect against liver ischemia reperfusion injury
Ischemia is defined by the arrest of blood flow in the organ cutting thus oxygen and metabolite supply indispensable for its survival and function. Restoration of blood flow in hypoxic tissue, called reperfusion, can ...
Polyhistidine repeats and Dyrk 1a: from the localization on the function
PolyHistidine repeats and DYRK1A: from the localization to the function<br/>El principal objectiu d'aquesta tesi ha estat el d'esbrinar noves funcions de la proteína quinasa DYRK1A en el nucli cel.lular. Donat que el domini ...
Polyhydroxyalkanoates production alongside wastewater treatment by mixed microbial cultures
El enfoque de este trabajo de investigación es analizar el proceso de producción de polihidroxialcanoatos (PHA) en paralelo al tratamiento de aguas residuales. Los PHA se consideran sustitutos potenciales de los plásticos ...
Polymer blends based on postconsumer waste of opaque poly(ethylene terephthalate) and polypropylene
(English) In recent years, new white and opaque PET bottles (PET-O) have appeared and are used for packaging dairy products. These bottles contain titanium dioxide (TiO2) particles to prevent deterioration of the packaged ...
Polymer supported and homogeneous organocatalysts for asymetric reactions: from batch to continuous flow applications
El objetivo general de esta tesis es establecer una ruta sintética para la inmovilización de organocatalizadores en soporte polimérico. En primer lugar, describimos el desarrollo de α,α-difenylprolinol metil/trimetilsilil ...
Polymer-zirconia based ceramic composites produced by 3D-printing
(English) Zirconia ceramic is widely used in numerous fields, such as electronics, machinery, and biomedical applications, due to its excellent properties as chemical resistance, thermal stability, electrical resistance, ...
