Targeting the RB pathway in tumor cells 

    Caballero de la Torre, María, 1992- (Date of defense: 2021-09-09)

    Retinoblastoma protein (RB) is a negative regulator of the cell cycle. In response to environmental stress, p38 MAPK phosphorylates RB in the N-terminal region, increasing the affinity of RB for E2F, repressing gene ...