Nicolini, Federica (Date of defense: 2022-12-02)
[eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. ...
Garcia Garcia, Josep (Date of defense: 2016-07-04)
During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of ...
López Asamar, Abraham (Date of defense: 2015-07-17)
Prolyl oligopeptidase (POP) is an 81-KDa bidomain enzyme which hydrolyses short proline-containing peptides. This enzyme is involved in mnemonic and cognitive processes, and the dysregulation of POP ...
Garcia Pindado, Júlia (Date of defense: 2017-05-12)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl ...
Dyachenko, Andrey (Date of defense: 2013-04-15)
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific ...
Goldflam, Michael (Date of defense: 2013-05-02)
The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development ...
Guardiola Bagán, Salvador (Date of defense: 2017-09-15)
Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed ...
Díaz Perlas, Cristina (Date of defense: 2018-03-07)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) ...
Rodríguez Mías, Ricard Aleix (Date of defense: 2006-10-05)
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present ...
Oller Salvia, Benjamí (Date of defense: 2015-05-18)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural ...