Rodríguez Cortez, Virginia Carolina (Date of defense: 2015-02-06)
The proper function of the immune system requires complex regulatory mechanisms and a highly strict balance in the amount and function of immune and non-immune elements. Part of the primary immunodeficiencies ...
Vargas Parra, Gardenía María (Date of defense: 2016-02-19)
BACKGROUND: MMR deficiency is a hallmark of tumors from Lynch syndrome LS) patients, who harbor germline mutations in MMR genes. No germline alterations are detected in a significant proportion of ...
García Rodríguez, Francisco J. (Date of defense: 2016-04-20)
In the last three decades, cisplatin has been one of the most widely prescribed drugs being an effective treatment for many cancer types. Despite its effectiveness, many patients are intrinsically ...
Vilarrasa Blasi, Josep (Date of defense: 2014-07-18)
The present PhD thesis work reports the molecular and genetic dissection for the role of plant steroid hormones Brassinosteroids (BRs) in root growth and development of Arabidopsis thaliana (Arabidopsis). ...
Guio Leiman, Laín (Date of defense: 2016-03-17)
Elucidating the fitness effects of natural genetic variants is one of the current major challenges in evolutionary biology. Understanding the interplay between genotype, phenotype and environment is ...
Palma Gudiel, Helena (Date of defense: 2019-02-15)
Psychiatric disorders are highly prevalent and one of the leading causes of disease burden worldwide. Nevertheless, there are no validated biomarkers to be used for either diagnostic or prognostic ...
Plazaola Sasieta, Haritz (Date of defense: 2018-11-29)
The chloride channel ClCN2 is expressed in glia in the mature nervous system of vertebrates and some physiological functions have been proposed. In addition, human patients with mutations in the gene ...
Casas Lamesa, Anna (Date of defense: 2018-11-21)
Histone H1 is a key determinant of higher-order chromatin structures and for a long time it has been considered a main transcriptional repressor. So consistent with its biochemical properties, the absence ...
Solà Vàzquez, Eduard (Date of defense: 2014-07-15)
Dugesia is a genus of free-living flatworms which species inhabit freshwater bodies across a wide distribution range that includes Africa, Madagascar, Eurasia and Australasia. They do not survive in ...
Rotstein Bajo, Bárbara (Date of defense: 2013-03-22)
A stereotyped tubular epithelial network forms many of our bodies’ organs and, defects in the formation of these tubules often leads to organ failure. My Thesis project aims to further understand the ...