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Showing 10 out of a total of 148 results for community: Universitat de Barcelona. (0.626 seconds)

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Synthesis, Biological Evaluation and Insights into the Mode of Action of Quinoxaline Containing Peptides

Zamudio Vázquez, Rubí (Date of defense: 14-02-2014)
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...
Structure, dynamics and interactions of the N-terminal domain of the androgen receptor

De Mol, Eva (Date of defense: 26-06-2014)
Prostate cancer (PCa) is the second most common cancer in men after lung cancer. Around 1.1 million men worldwide were diagnosed with PCa in 2012. PCa depends essentially on androgen stimulation for growth and cell survival. ...
SOX11 transcription factor functional analysis in aggressive MCL

Vegliante, Maria Carmela (Date of defense: 26-09-2013)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified as a very specific ...
The epigenetic regulation of cell cycle and chromatin dynamic by sirtuins

Martínez Redondo, Paloma (Date of defense: 25-06-2014)
The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded in the DNA. The ...
Estratègies de millora de la potència antitumoral dels adenovirus oncolítics basades en l’increment de l’alliberament viral i l’extravasació vascular

Puig Saus, Cristina (Date of defense: 15-07-2013)
La viroteràpia amb adenovirus oncolítics es basa en la lisi selectiva de la cèl•lula tumoral a través de la replicació viral. Les principals limitacions d’aquesta teràpia són: la limitada arribada del virus al tumor després ...
Adenovirus oncoselectius pel tractament de càncer de pàncrees. Combinació d'estratègies de direccionament a tumor i bioselecció de microRNAs potenciadors de l'activitat adenoviral

Rovira i Rigau, Maria (Date of defense: 08-09-2017)
L’adenocarcinoma ductal pancreàtic (PDAC) és una neoplàsia molt agressiva a conseqüència de la seva elevada capacitat metastàtica i la gran resistència que presenta als tractaments convencionals de quimioteràpia i radioteràpia. ...
Mantle cell lymphoma pathogenesis: another turn of the screw to cyclin D1 overexpression

Albero Gallego, Robert (Date of defense: 21-07-2017)
Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm derived from mature B cells characterized by the presence of the t(11;14)(q13;q32) translocation that leads to the overexpression of Cyclin D1. Cyclin D1 plays ...
Role of ZEB1 in macrophages during homeostasis, inflammation and cancer

Cortés Hinojosa, Marlies (Date of defense: 26-05-2017)
ZEB1 is a transcription factor whose expression in cancer cells promotes tumor initiation and progression. In this study, we for the first time characterized Zeb1 and study its function in macrophages under either homeostasis ...
Innovative targeted therapies for chemorefractory B-cell non-Hodgkin lymphomas

Esteve Arenys, Anna (Date of defense: 22-12-2017)
Lymphomas are a heterogeneous group of tumors characterized by the proliferation of lymphocytes predominantly in lymphoid structures but also in extranodal tissues. More than 90% of patients are afflicted by lymphomas ...
Detecció de carcinoma basocel·lular residual en seccions de cirurgia de Mohs mitjançant microscòpia confocal de fluorescència ex vivo. Descripció de criteris i aplicabilitat clínica

Bennàsar Vicens, Antoni (Date of defense: 19-12-2014)
La cirurgia de Mohs (CMM) amb control intraoperatori microscòpic dels marges garanteix la negativitat dels marges quirúrgics al final de la intervenció amb el mínim malbaratament de pell sana perilesional. Tanmateix, aquesta ...