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Showing 10 out of a total of 475 results for community: Universitat de Barcelona. (7.822 seconds)

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Elucidating catalytic mechanisms of glycoside hydrolases and transferases by means of ab initio molecular dynamics simulations

Iglesias Fernández, Javier (Date of defense: 19-09-2014)
Carbohydrates play a central role in transport and storage of energy and as molecular building blocks. Additionally, glycoconjugates, specifically glycoproteins and glycolipids, are important components of cell surfaces ...
Protein dynamics studied by coarse-grained and atomistic theoretical approaches

Orellana, Laura (Date of defense: 30-05-2014)
Protein structure, dynamics and function, are inseparable in order to understand the mechanisms of Life at the molecular level. From the structure comes dynamics, and from dynamics many, if not all, protein functions. ...
Characterization of Rpn10 monoubiquitination as a novel way of proteasome regulation

Isasa Catalán, Marta (Date of defense: 19-07-2012)
Targeted protein degradation plays a central role in eukaryotic cell regulation and homeostasis. The ubiquitin proteasome system (UPS) is involved in a large number of cellular events, being, day by day, more difficult to ...
Protein Flexibility: From local to global motions. A computational study

Sánchez Martínez, Melchor (Date of defense: 09-12-2014)
Proteins are flexible entities, and thus move. Its function is closely related to the flexibility. To carry out any function is necessary a conformational change. As protein motions imply an exchange of conformations, ...
Structure, dynamics and interactions of the N-terminal domain of the androgen receptor

De Mol, Eva (Date of defense: 26-06-2014)
Prostate cancer (PCa) is the second most common cancer in men after lung cancer. Around 1.1 million men worldwide were diagnosed with PCa in 2012. PCa depends essentially on androgen stimulation for growth and cell survival. ...
Nucleosome positioning on chromatin using bioinformatics techniques = Posicionament de nucleosomes en cromatina emprant tècniques bioinformàtiques

Flores Guri, Oscar (Date of defense: 10-06-2014)
This thesis presents a broad study of the chromatin structure and function with special focus in the nucleosome organization. More specifically, it includes three different but complementary perspectives: i) Analysis of ...
Modeling cytokine signaling pathways for the study of autoimmune disease

Pertsovskaya, Inna (Date of defense: 25-06-2014)
Systems Biology opens new frontiers in the studies of complex diseases such as Multiple Sclerosis (MS). The questions that couldn’t be addressed before due to lack of understanding and methodological base, such as the ...
New insights into carotenoid accumulation in tomato fruit = Nuevos aspectos sobre acumulación de carotenoides en el fruto del tomate

Pourcq, Karel de (Date of defense: 24-01-2014)
Lycopene is an antioxidant carotenoid present in high amounts inside the ripe tomato fruit, in watermelon, red bell pepper and a few other red-pigmented fruits. Its health benefits, notably the prevention of prostate cancer ...
Polypurine Reverse Hoogsteen hairpins: stability, lack of immunogenicity and gene silencing in cancer therapy

Villalobos Alberú, Xenia (Date of defense: 22-12-2015)
This work is focused on the study of the stability and immunogenic properties of the Polypurine Reverse Hoogsteen hairpins (PPRHs), and on their use as a gene-silencing tool. PPRHs are non-modified DNA molecules formed by ...
Estudio de los mecanismos terapéuticos en la inducción de tolerancia inmunológica en un modelo animal de esclerosis múltiple

Gómez Morago, Alba (Date of defense: 10-02-2016)
La terapia génica puede ser una herramienta para inducir tolerancia inmunológica de forma experimental. Nuestro trabajo anterior mostró que la transferencia de células de médula ósea que habían sido transducidas con un ...