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Showing 10 out of a total of 15 results for community: Universitat de Barcelona. (0.358 seconds)

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Combined use of NMR and computational tools for fragment based drug discovery targeting protein-protein interactions VEGF protein surface recognition as a case study

Goldflam, Michael (Date of defense: 02-05-2013)
The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or ...
From bee venom to blood-brain barrier shuttles. Development of minimized apamin derivatives for brain delivery of antibodies and other cargoes

Oller Salvia, Benjamí (Date of defense: 18-05-2015)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...
N-Myristoylation-Dependent c-Src Interactions

Le Roux, Anabel-Lise (Date of defense: 18-11-2015)
c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the ...
Protease inhibitors as therapeutic agents

Mendieta Martínez, Laura (Date of defense: 06-06-2014)
Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study in four proteases: ...
Study of the aggregation process of the amyloid beta-protein associated to Alzheimer's disease. Examination of pharmaceutically important small molecules.

Serra Vidal, Bernat (Date of defense: 27-05-2014)
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β (Aβ) protein ...
Molecular recognition in gas phase: theoretical and experimental study of non-covalent protein-ligand complexes by mass-spectrometry

Dyachenko, Andrey (Date of defense: 15-04-2013)
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
New strategies based on nanosystems to facilitate the crossing through biological barriers

Garcia Garcia, Josep (Date of defense: 04-07-2016)
During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of peptides combined ...
Synthesis of biaryl bicyclic peptides for recognition of protein surfaces

Garcia Pindado, Júlia (Date of defense: 12-05-2017)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Cyclic peptides and small proteins in molecular recognition

Ciudad Fernández, Sonia (Date of defense: 08-11-2016)
The present thesis is based on the work developed about the use of peptides and small proteins in protein surface molecular recognition. Peptides present several advantages when compared with small molecules and biologics: ...
Design, synthesis and biophysical evaluation of peptides targeting pharmacologically relevant proteins

Guardiola Bagán, Salvador (Date of defense: 15-09-2017)
Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed to provide effective ...