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Showing 6 out of a total of 6 results for community: Universitat de Barcelona. (0.283 seconds)

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From bee venom to blood-brain barrier shuttles. Development of minimized apamin derivatives for brain delivery of antibodies and other cargoes

Oller Salvia, Benjamí (Date of defense: 18-05-2015)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...
Synthesis of biaryl bicyclic peptides for recognition of protein surfaces

Garcia Pindado, Júlia (Date of defense: 12-05-2017)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Diseño, síntesis y estructura de dominios helicoidales. Influencia de la introducción de aminoácidos D.

Granados Ramírez, Carmen Giovana
1) "Diseño, síntesis y caracterización de inhibidores de la fusión de VIH-1 análogos del péptido C34 de gp41 con D aminoácido"En el proceso de fusión del virus del VIH-1 a la célula diana intervienen las proteínas de la ...
Blood-Brain Barrier Shuttles: From Design to Application

Arranz Gibert, Pol (Date of defense: 12-01-2017)
The work of this thesis is based on research on peptides able to cross the blood-brain barrier and their use as tools to enable the delivery of drugs into the brain. The blood-brain barrier (BBB) is a permeable but ...
Development of new antimicrobial peptides and peptidomimetics and mechanism of resistance to peptide antibiotics

Vila Farrés, Xavier (Date of defense: 14-11-2014)
Nowadays in the world there is a very big problem associated with two factors related to each other. The first factor is the increase in the resistant of certain bacteria, especially the bacteria from the ESKPAE group. The ...
From phage display and venoms to protease-resistant peptides: Design of BBB-shuttles and peptides targeting EGF

Díaz Perlas, Cristina (Date of defense: 07-03-2018)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) and as new BBB-shuttles, ...