The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or ...
Oller Salvia, Benjamí(Date of defense: 18-05-2015)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...
c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the ...
En la presente tesis doctoral se ha desarrollado una nueva estrategia de química combinatoria para la modificación de la hélice alfa C-terminal del dominio B de la proteína A de Staphylococcus Aureus, extensible a la ...
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
El comportament reproductor en moltes espècies d'insectes implica l'alliberament per part de la femella d'una sèrie de compostos químics volàtils, anomenats feromones, els quals són detectats de forma molt específica, a ...
During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of peptides combined ...
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present thesis we propose ...
Garcia Pindado, Júlia(Date of defense: 12-05-2017)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Ciudad Fernández, Sonia(Date of defense: 08-11-2016)
The present thesis is based on the work developed about the use of peptides and small proteins in protein surface molecular recognition.
Peptides present several advantages when compared with small molecules and biologics: ...