Home

What is it?

Search

Filters

Use filters to refine the search results.

Current Filters:


New Filters:

Showing 10 out of a total of 19 results for collection: Departament de Química Orgànica. (2.186 seconds)

Now showing items 1-10 of 19

Sort Options:
Results Per Page:
- 5
- 10
- 20
- 40
- 60
- 80
- 100

Combined use of NMR and computational tools for fragment based drug discovery targeting protein-protein interactions VEGF protein surface recognition as a case study

Goldflam, Michael (Date of defense: 02-05-2013)
The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or ...
From bee venom to blood-brain barrier shuttles. Development of minimized apamin derivatives for brain delivery of antibodies and other cargoes

Oller Salvia, Benjamí (Date of defense: 18-05-2015)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...
N-Myristoylation-Dependent c-Src Interactions

Le Roux, Anabel-Lise (Date of defense: 18-11-2015)
c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the ...
Nueva estrategia de química combinatoria para el diseño y modificación de dominios proteicos, Una

Pastor Porras, José Javier
En la presente tesis doctoral se ha desarrollado una nueva estrategia de química combinatoria para la modificación de la hélice alfa C-terminal del dominio B de la proteína A de Staphylococcus Aureus, extensible a la ...
Molecular recognition in gas phase: theoretical and experimental study of non-covalent protein-ligand complexes by mass-spectrometry

Dyachenko, Andrey (Date of defense: 15-04-2013)
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
Desasturases de membrana: estudis mecanístics, clonatge i aplicacions biotecnològiques

Rodríguez Ropero, Sergio
El comportament reproductor en moltes espècies d'insectes implica l'alliberament per part de la femella d'una sèrie de compostos químics volàtils, anomenats feromones, els quals són detectats de forma molt específica, a ...
New strategies based on nanosystems to facilitate the crossing through biological barriers

Garcia Garcia, Josep (Date of defense: 04-07-2016)
During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of peptides combined ...
NMR in drug discovery. From screening to structure-based design of antitumoral agents

Rodríguez Mías, Ricard Aleix
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present thesis we propose ...
Synthesis of biaryl bicyclic peptides for recognition of protein surfaces

Garcia Pindado, Júlia (Date of defense: 12-05-2017)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Cyclic peptides and small proteins in molecular recognition

Ciudad Fernández, Sonia (Date of defense: 08-11-2016)
The present thesis is based on the work developed about the use of peptides and small proteins in protein surface molecular recognition. Peptides present several advantages when compared with small molecules and biologics: ...